Objective: To evaluate enuresis-induced antiepileptic drugs in children. Data Sources: A PubMed search (1917 to July 2020) was performed using the following keywords and associated medical subject headings: antiepileptic drugs, enuresis, pediatric population, drug-induced enuresis, and epilepsy. Study Selection and Data Extraction: The search was conducted to find the role of antiepileptic drugs–induced enuresis in children in studies published in English. Data Synthesis: Enuresis or bedwetting is an underreported adverse drug reaction of antiepileptic drugs. Owing to that fact, it is a condition that is outgrown with age and also could cause embarrassment. As antiepileptic drugs sometimes need to be taken for a long duration until epilepsy relapses, the occurrence of enuresis in this situation can be troublesome for both the child and the caretaker. Even though enuresis is proposed to have a significant effect on the child’s psychology, it is still considered to be a condition that is outgrown with age. This article includes a review of antiepileptic drugs reported to have caused enuresis in children. Conclusions: If a child develops enuresis as an adverse drug reaction, this adds further challenges to their life. A better understanding of this potential adverse effect may help prevent unwanted stress. Though the exact mechanisms are not known, the hypothesis generated is from the occurred cases, most of which relapsed when the drug was withdrawn. Considering the gravity of epilepsy in children, more detailed studies need to be conducted on this adverse effect to ensure a safe and effective treatment in children.

Objectives: Enuresis or bedwetting is considered to be an underreported ADR of antiepileptic drugs (AEDs). This study assesses the incidence and comparative rate of occurrence of enuresis in children with epilepsy who are on AEDs treatment such as sodium valproate (SV); carbamazepine and levetiracetam (LEV). Methods: The study was conducted with a sample size of 32 patients. Both inpatients and outpatients between the age group >5–18 years of age previously diagnosed with epilepsy that is on monotherapy and polytherapy with SV or carbamazepine or LEV were included in the study. Patients with urinary complications or urogenital abnormalities past 3 months before admission were excluded from the study. Assessment of enuresis was done based on a questionnaire prepared from NICE guidelines and analyzed using SPSS software version 20. Results: Of 44 patients who were included in the study, only 34 came for review. Analysis of the questionnaire showed the occurrence of enuresis in 12 patients. Drugs prescribed versus assessment questions showed potent significance with eight questions; hence the hypothesis that the prescribed drugs can cause enuresis can be taken into consideration. The rate of occurrence of enuresis was analyzed in all the drugs with their respective doses, but the significant values were found only for SV 200 mg. Conclusion: This study shows the possibility of enuresis in LEV and SV treatment with a significant difference in SV. Furthermore, it showed a relation between the duration of treatment and the occurrence of enuresis.