E-cadherin mutations are a major step in the metastatic progression. Mutated cadherins contributes to different aspects of cancer progression like drug resistance, angiogenesis, cancer cell invasion and metastasis. Thus cadherins can be regarded as a valuable diagnostic and prognostic indicators as well as potential therapeutic targets of cancer therapy in future. Identification of E-cadherin mutations and characterization of the mutated protein may improve our understanding of how cells escape from their normal location and spread through the body. The present study aimed at analyzing the functional consequences of such E-cadherin mutations in 50 patients with infiltrating ductal carcinoma of the breast.