Purpose: To evaluate the knowledge, opinions and prescribing attitudes of physicians working in an university hospital about biosimilar drugs and analyse the factors affect these parameters. Methods: In this descriptive, cross-sectional study, data was collected using a questionnaire consisting of 5 sections and 41 questions evaluating the knowledge, opinions and prescribing attitudes of physicians about biosimilar drugs. Descriptive statistics was used to report the findings; relationship between dependent and independent variables were examined using the t-test for parametric data, and Mann Whitney U and Kruskall Wallis analysis for nonparametric data. P <0.05 was considered statistically significant. Results: Questionnaire response rate was 61.9% (n=114). Physicians mean knowledge score about biosimilar drugs was 7.6 ± 2.5 out of 14 points. Have heard the concept the biosimilar drug, had training towards biosimilar drugs and high academic level were increased the mean knowledge score. Of the respondents, 45.2% of the physicians stated that biosimilar drugs are not as effective as biological reference drugs, and 35.9% thought that they aren't safe. More than half of the physicians (56.6%) stated that they did not hesitate to prescribe biosimilar drugs. Conclusions: Physicians' general knowledge level on biosimilar drugs was low and they had doubts about the efficacy and safety of biosimilar drugs. This might be related with lack of knowledge. Therefore structured training programmes related in this area, might increase the knowledge level and might positively affect physicians' opinions and attitudes on biosimilar drugs

Aim: The aim of this study is to compare the fractures seen before and during the pandemic in individuals over the age of 65. Method: The universe of this cross-sectional study consists of elderly patients with a fracture diagnosis between 01.09.2018-30.08.2021 at University Hospital. Results: In the pre-pandemic periods, the total number of elderly patients diagnosed with fractures is 509. 57.06 % of the patients are women. The average age was founded as 76.7± 8.2 (65 - 106).The most common type of accidents that cause fractures with 85% are low energy accidents 70.9% of the elderly admitted with fractures under went surgical intervention. The total number of patients diagnosed with fracturesis 736 during the pandemic period. 53.3% (n=394) are women. The average age is 76.1± 8.2 (65-105).The most common fractures observed in patients are femur fractures.42.7% of this rate is significantly lower than before the pandemic (p=0.002).The most common type of accidents caused fractures significantly higher rate (89.2%) are low energy accidents (p=0.027).63.9% of fractures seen during the pandemic period underwent surgical intervention. The surgical intervention rate was significantly lower than before the pandemic (p=0.010). Conclusion: When the data obtained in this study are evaluated, it appears that the fractures occured during the pandemic period have increased numerically compared to the pre-pandemic period.

Objective: Cancer-related deaths in all countries of the world, including our country, come second after deaths caused by cardiovascular diseases. Covid-19 is a pandemic disease affecting many organs but primarily the lung. The aim of this study is to compare the cancer incidences in the pre-Covid-19 period and during Covid-19 pandemic period in Sivas province by means of age, gender and cancer type distribution of the patients. Methods: The population of the study consists of the patients who applied to health institutions in Sivas between 01.11.2018 and 30.06.2021 and were diagnosed as cancer for the first time. The dependent variable of the study is cancer incidence. The independent variable was the 16 monthstime period comprising before Covid-19 pandemic and during the pandemic period seperately. In addition, patients diagnosed with cancer in both periods are evaluated and compared according to age groups, gender and the type of cancer. Results: In this study, the pre-pandemic period and the pandemic period were compared. It was determined that 1355 patients were diagnosed as cancer during the pre-pandemic period and 1720 patients during the pandemic period. The incidence, which was 212.1 per hundred thousand in the previous period, increased to 270.5 per hundred thousand during the 16-month pandemic period. Conclusion: When the data obtained in our study are compared, it is seen that the incidence of cancer increased during the pandemic period compared to the pre-pandemic period.