No abstract

Stem cells exist as normal cells in embryonic and adult tissues. In recent years, scientists have spared efforts to determine the role of stem cells in treating many diseases. Stem cells can self-regenerate and transform into some somatic cells. They would also have a special position in the future in various clinical fields, drug discovery, and other scientific research. Accordingly, the detection of safe and low-cost methods to obtain such cells is one of the main objectives of research. Jaw, face, and mouth tissues are the rich sources of stem cells, which more accessible than other stem cells, so stem cell and tissue engineering treatments in dentistry have received much clinical attention in recent years. This review study examines three essential elements of tissue engineering in dentistry and clinical practice, including stem cells derived from the intra- and extra-oral sources, growth factors, and scaffolds.

Purpose. Guided tissue reconstruction can be performed to restore the supporting structure of a previously lost tooth, which, in addition to maintaining beauty, preserves the function of the tooth in the patient. Materials and Methods. In this review, Scopus, PubMed, and MEDLINE databases were searched using the keywords “biocompatible materials,” “membrane,” “bone regeneration,” “tissue reconstruction,” and “dental biomaterials.” Overall, 150 articles were reviewed, and finally, 107 articles published during 2000–2021 were included in the final paper. Results. Studies have been conducted on a variety of membranes in both clinical and experimental settings. The first half of this article explores the different kinds of membranes and diverse classes of biomaterials used in these procedures. Secondly, biomaterials are examined for their therapeutic uses such as growth factors, stem cells, and gene delivery vehicles. Conclusion. If a tooth has been extracted or if the gums have been infected with periodontal disease, guided bone regeneration procedures may be used to restore the lost bone. Recent years have seen a variety of approaches to regenerating these tissues. To prevent nonossifying cells from entering, membranes are heavily employed during guided rebuilding.

To assess the influence of systemic sclerosis (SSc) on the survival rate of dental implants in SSc patients receiving implant-supported treatments. Methods: The Preferred Reporting Items for Systematic Reviews and Metaanalysis (PRISMA) Statement and the Cochrane Collaboration's guiding principles were followed during the study's execution. The data from three databases, PubMed, Google Scholar, and Scopus, available until January 2023, were used to compile the material for our research. Only English-language publications were submitted for this research and evaluated based on their titles, abstracts, and full texts. For performing a quality assessment, quality scores were calculated. Results: The total number of patients and implants studied were 37 and 153, respectively, all having had scleroderma. The patients' ages ranged from 28 to 77 years old, with a mean (SD) age of 58.16 (12.88). All the patients in the case reports and most in the case series study were female. The range of follow-up duration was from 1 to 10 years. In case report studies, the survival rate was 100%; in case series, it was 89.2%. Conclusion:The SSc status had no discernible impact on the implant survival rate. Implant-based treatments in SSc patients should not worsen the overall morbidity and should not conflict with systemic treatments. Before starting implant therapy, a thorough risk assessment is essential, though.