<p><span>Immune system content along with body defense mechanism tends to be an abstract content that is hard to comprehend by students. Digital flipbook learning media become an innovative learning medium to facilitate the immune system content understanding for students. Method used in the research is ADDIE research and development with the following stages: analysis, define, design, implement, and evaluation. The research is limited to the development stage. The number of respondents in the research consists of 30 senior high school students aged 17-19 years and 3 (three) Biology teachers aged 30-40 years for needs analysis. Learning media expert validation includes 3 (three) teachers and ten students for small group test. The medium is developed using applications of Microsoft PowerPoint 2010, Movavi Video Editor 14 and Flip PDF Professional. The assessment results of Digital Flipbook Imunopedia (DFI) learning media development by the three Biology education experts indicate valid and feasible to be used in immune system learning process. Average of each feasibility test aspect is content aspect (3.05), media aspect (2.95), and language aspect (2.95). The trial test results to small group regarding the DFI content, display, and benefits indicate a very feasible criterion (3.62).</span></p>

The research purpose is to analyze digital flipbook immunopedia (DFI) learning media implementation for immune system concept mastery improvement. The research method used quasi-experimental method with one group pretest-posttest design. The research carried out at SMAN 1 Cibinong, Indonesia in Grade XI of MIPA. Samples consisted of 62 students. Instruments used in the research were in the form of multiple-choice questions of 40 questions. The instrument grid refered to a revised Bloom’s Taxonomy levels with indicators of C1 to C6. The instruments were valid and had a significantly high reliability. The Wilcoxon test result of 0.000 indicated the effect of DFI on learning. Average total result of Normalized Gain was 0.81, which was high and the Effect Size test result was 2.37 indicating a strong effect. It proved that DFI could improve the immune system concept mastery. The immune system learning should utilize digital learning media, such as flipbook that could assist in the achievement of concept mastery.