Nowadays, cold atmospheric plasma shows interesting results in dermatology. In the present study, a new portable cold plasma was designed for plasma skin rejuvenation (PSR) purposes. This device is safe and easy to use at beauty salons and homes. The effects of this device were investigated on the rat skins. Also, as a new method to improve PSR results, vitamin C ointment was combined with plasma. In this study, there were four groups of 5 Wistar rats. The first group received vitamin C ointment, the second received 5 min of high-voltage plasma, and the third and the fourth groups received 5 min of high- and low-voltage plasma and vitamin C ointment. This process was done every other day (3 sessions per week) for 6 weeks. To evaluate the thermal effect of plasma, the skin temperature was monitored. Also, the presence of reactive species was demonstrated by the use of optical spectroscopy. In addition, mechanical assays were performed to assess the effect of plasma and vitamin C on the tissue’s mechanical strength. The mechanical assays showed a positive impact of plasma on the treated tissue compared to the control group. Also, changes in the collagen level and thickness of the epidermal layer were examined in histological studies. The results indicated an increase in collagen levels after using plasma alone and an accelerated skin reaction after using vitamin C combined with plasma therapy. The epidermal layer’s thickness increased after applying high-voltage plasma, which indicates an increase in skin elasticity. This study demonstrates the positive effect of using the portable plasma device with vitamin C ointment on effective parameters in skin rejuvenation.

The aim of this study is to evaluate the efficacy and safety of cold atmospheric plasma (CAP) as a novel therapy for diabetic foot ulcers. This was an investigatorblinded, randomized controlled trial of 14 weeks (6 weeks of treatment and 8 weeks of follow-up). Twenty patients with diabetic foot ulcers were divided into two groups: the control group receiving standard wound care and the plasma group, which received CAP twice a week for six consecutive weeks in addition to standard wound care. The ulcer size, amount of exudate, and wound grading were determined weekly. Cold plasma was produced by applying a high voltage (4.5 kV) and a high frequency (22 kHz) to helium gas. Exudate from wounds treated with CAP showed a significant reduction in the third week after complete treatment (p = 0.039). The wound grading of the ulcers improved by the sixth week (p = 0.019), and the sizes of ulcers significantly decreased in the plasma group at the end of the treatment period (p = 0.007). In this randomized clinical trial, CAP was an effective treatment option for diabetic foot ulcers in terms of wound surface reduction and antibacterial effects.

The partitioning of magnetic field energy and plasma energy during the penetration of the magnetic field into the plasma, in a time scale much larger than the electron cyclotron period, is studied. We solve numerically a two-dimensional model problem assuming that the plasma is unmagnetized initially. Plasma-directed kinetic and heat energies are calculated. Numerical results show that the partitioning of the magnetic field energy and the plasma energy is sensitive to the time dependence of the magnetic field at the plasma boundary. When the magnetic field at the boundary of the plasma remains constant with the onset of time, the magnetic field energy is equal to the plasma energy. On the other hand, the numerical result is consistent with the experimental result for the time dependence of the magnetic field B=B0 tanh(t/τ).

The penetration of a magnetic field into a cylindrical plasma, in the time scale that is much longer than electron cyclotron period, is studied. A linear wave analysis is shown that the magnetic field penetrates rapidly into the plasma in radii smaller than the ion skin depth. Due to the axial symmetry, the problem reduces to a twodimensional problem. The magnetic field evolution is numerically calculated. The ion density is also calculated. It is shown that during the penetration of the magnetic field, a gap appears between cathode and plasma. At the early times, at the plasma boundary, electrons move radially, and coupling of the electron velocity and the electric field induces the magnetic field. Electrons then gain a drift due to the field curvature that results in fast penetration of the magnetic field into the plasma.