Introduction: Pleomorphic adenoma is one of the most common salivary gland neoplasms, with the parotid gland being the most affected site and a lower incidence in the minor salivary glands. This article reports an unusual clinical case of pleomorphic adenoma of minor salivary gland, located in the buccal mucosa and presents its treatment.Case Report: A 65-year-old female patient with a lesion in the buccal mucosa with evolution of approximately two years was evaluated. The anatomopathological report after incisional biopsy indicated pleomorphic adenoma. The treatment performed was a complete excision of the lesion under local anesthesia. The specimen, measuring 20.51 mm, was sent for anatomopathological examination, whose report confirmed the previous diagnosis. Conclusion:The complete excision of pleomorphic adenoma of minor salivary gland in the buccal mucosa under local anesthesia allowed the patient to heal and prevented a possible malignant transformation, with little associated morbidity.

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