Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1) led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR), gorilla (Gorilla gorilla, GGO) and orangutan (Pongo pygmaeus, PPY) chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to the chromosome 5q31-specific DNA probe were observed at HSA 5q31, PTR 4q31, GGO 4q31 and PPY 4q31, while fluorescent signals using the chromosome 10q22-specific DNA probe were noted at HSA 10q22, PTR 8q22, GGO 8q22 and PPY 7q22. The chromosome arms showing hybridization signals to the Quint-EssentialTM 13-specific DNA probe were identified as HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 and PPY 14q32-33, while those presenting hybridization signals to the chromosome 19q13.1-specific DNA probe were identified as HSA 19q13.1, PTR 20q13, GGO 20q13 and PPY 20q13. All four probes presumably hybridized to homologous chromosomal locations in the apes, which suggests a homology of certain unique DNA sequences among hominoid species.
Homologias entre os padrões de bandamento de cromossomos e seqüências de DNA em grandes macacos e humanos sugerem uma aparente origem comum para estas duas linhagens. A disponibilidade de sondas de DNA para regiões específicas de cromossomos humanos (5q31, 10q22, 13q32-33 e 19q13.1) nos levou a realizar hibridação cruzada com cromossomos de chimpanzé (Pan troglodytes, PTR), gorila (Gorilla gorilla, GGO) e orangotango (Pongo pygmaeus, PPY) em um pesquisa de regiões equivalentes em grandes macacos. Sinais positivos de hibridação para a sonda de DNA específica para o cromossomo 5q31 foram observados em HSA 5q31, PTR 4q31, GGO 4q31 e PPY 4q31, enquanto que sinais fluorescentes usando a sonda de DNA específica para o cromossomo 10q22 foram notados em HSA 10q22, PTR 8q22, GGO 8q22 e PPY 7q22. Os braços de cromossomos apresentando sinais de hibridação para a sonda de DNA específica para Quint-EssentialÒ 13 foram identificados como HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 e PPY 14q32-33, enquanto que aqueles apresentando sinais de hibridação para sonda de DNA específica para o cromossomo 19q13.1 foram identificados como HSA 19q13.1, PTR 20q13, GGO 20q13 e PPY 20q13. Todas as quatro sondas presumivelmente hidridizaram para locais cromossômicos homólogos nos símios, o que sugere uma homologia de certas seqüências únicas de DNA entre as espécies hominóides
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