This is the first study using individual-level patient data to study maternal perchlorate exposure and offspring neurodevelopment and suggests that high-end maternal perchlorate levels in hypothyroid/hypothyroxinemic pregnant women have an adverse effect on offspring cognitive development, not affected by maternal levothyroxine therapy. These results require replication in additional studies, including in the euthyroid population.

Type 1 Diabetes (T1DM) is a common chronic disease in children and young people. Living

Young people in care are known to have high levels of aggressive behaviors and high levels of self-esteem, and these difficulties continue into adult life. Previous research has suggested that there is a relationship between self-esteem and aggression, although the nature of this relationship is unclear and possible differences due to gender have rarely been explored. Therefore, the relationships between different forms of selfesteem (global self-esteem, social rank, social fit, and attractiveness) and aggression were investigated in a sample of young care-leavers. For men, high levels of social rank and high levels of attractiveness were predictive of aggression, whereas for women low levels of perceived social inclusion and low levels of attractiveness were predictive of aggression. These findings suggest that there are significant gender differences in the relationship between self-esteem and aggression in care-leavers and that using domainspecific measures of self-esteem provides a richer understanding of these relationships.They also suggest that a more targeted approach to intervention is needed.

As members of a Paediatric Diabetes Multidisciplinary Team, we have become increasingly concerned by the number of young people we are seeing who have Type 1 diabetes (T1D) and have developed, or are developing, complex relationships with food. Colleagues in other diabetes services have expressed similar concerns. In recent years a number of people who have T1D and are struggling with eating disorders have publicly shared their stories, notably in a widely viewed TV documentary (Hughes-Hallet, 2017) and also across social media platforms. This is still a relatively new area for both clinicians and researchers, and there is still much to be learnt about how to best prevent, assess and treat eating disorders in the context of T1D. We are therefore delighted to introduce this Special Issue of Clinical Child Psychology and Psychiatry, which brings together a range of informative and thought-provoking papers on this topic.Eating Disorders are characterised by "persistent disturbance of eating or eating-related behaviour that results in the altered consumption or absorption of food and that significantly impairs health or psychosocial functioning" (APA, 2021). Eating disorders include conditions such as Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding Eating Disorder and Avoidance/Restrictive Food Intake Disorder. Eating disorders can be extremely serious, and have the highest rates of mortality across all mental health conditions (Arcalus et al., 2011).It is thought that eating disorders affect approximately 2-4% of the population at some point during their lifetime (Galmiche et al., 2019;Smink et al., 2012;Young et al., 2013). In addition, there are signs that the prevalence of eating disorders (the proportion of the population that meet the criteria for an eating disorder at a single point in time) may be increasing. A recent systematic review (Galmiche et al., 2019) found that the global prevalence of eating disorders had increased from 3.5% to 7.8% between 2000 and 2018. It is also thought that COVID-19 restrictions have led to a further rise in body image concerns (Robertson et al., 2021;Solmi et al., 2021). People living with T1D are twice as likely to present with an eating disorder as their peers (Young et al., 2013).Type 1 diabetes (T1D) is an autoimmune disease defined by insulin deficiency. When untreated or managed inappropriately, it can lead to Diabetic Ketoacidosis (DKA), a life-threatening condition. Treatment involves addressing this deficiency via exogenous insulin therapy, and modern diabetes treatments involve insulin injections or insulin pump therapy. Insulin doses depend on the amount of carbohydrate consumed and blood glucose levels (with consideration of exercise/activity levels and illness as relevant). Target ranges for blood glucose levels are set in order to minimise

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