CV205-502 is a new non-ergot dopamine agonist currently being studied for the treatment of hyperprolactinaemia. We have assessed the effects of CV205-502 on prolactin secretion and the clinical consequences of hyperprolactinaemia in 16 patients with hyperprolactinaemia who had previously been unsuccessfully treated with bromocriptine. These patients had been either intolerant of and/or resistant to the effects of bromocriptine. Sixteen patients, all women in an age range between 20 and 49 years (mean 31.5 years), were treated for periods of between 8 and 52 weeks with doses of CV205-502 ranging from 0.075 to 0.3 mg taken once daily at night. Seven out of 10 of the patients, who were intolerant of bromocriptine, tolerated CV205-502 better with fewer side effects although the nature of the side effects was similar to that associated with bromocriptine. Only 1 patient from this group stopped taking CV205-502 due to side effects. Six of 11 patients exhibiting bromocriptine resistance showed a significant reduction in the degree of hyperprolactinaemia but normoprolactinaemia was achieved in only 1. Galactorrhoea ceased in 2 of 6 patients, menstruation resumed in 6 of 11 patients presenting with amenorrhoea, and 2 patients conceived. In patients with bromocriptine intolerance and/or resistance, CV205-502 is useful as a second line treatment.

Background: Sudden cardiac arrest has become a serious pandemic and a substantial public health burden. Significant morbidity and death are linked to it. Hemodialysis is considerably a heavy burden on cardiac patients. A sudden cardiac arrest is sometimes a disastrous event that happens without warning and is regrettably a significant cardiac disease manifestation in individuals surviving on kidney dialysis. Aim: To determine Serum Hemoglobin and potassium levels in sudden cardiac death patients admitted in hemodialysis center of Aziz Bhatti Shaheed Teaching Hospital Gujrat. Study Design: Cross-Sectional Study Methodology: This research study was conducted at the hemodialysis center of Aziz Bhatti Shaheed Teaching Hospital Gujrat. The Ethics Committee approved to conduct of this descriptive cross-sectional study on 40 (20 males and 20 females) sudden cardiac patients. All information and the goal of the research project were explained to patients or their relatives before the collection of blood serum. Prescription drug lists, smoking histories, and medication or dialysis report data were randomly evaluated. Laboratory results from recent month were collected, together with dialysis run sheets and cardiac arrest data forms. Results: Results of this result study showed that the mean value of age was 50 years with a mean standard deviation of 15.1 (p= <0.001). The mean BMI (kg/m2) was estimated as 26.8 with a mean standard deviation value of 2.6 (p= 0.01). Almost 21.6% of male patients were smokers and overall 36.1% were associated with cardiac arrest due to coronary artery disease. Systolic blood pressure (mmHg) was 165 (95% CI of 117-140) (p= <0.001), diastolic blood pressure (mm Hg) was 89 ( 95% CI of 64-72) (p= <0.001), hemoglobin level was 0.73 (95% CI of 0.70-0.76) (p= <0.001), Hemoglobin A1 c was 6.4% (95% CI of 5.8-7.6) (p= <0.001), Urea was 56 (95% CI of 41-79) (p= <0.001), and estimated glomerulus filtration rate (mL/min per 1.73mm2 ) was 1.16 (1.10-1.22) in sudden cardiac patients with low K (serum <4.0mmole/L). For the sudden cardiac patients with higher K level (serum >4.0mmole/L) showed that there was a significant change in the estimated values i.e. estimated glomerular filtration rate (mL/min per 1.73 mm2) was 0.67 (95% CI of 0.54-0.58) (p=<0.01). The practical implication of this research study suggests that the higher proportion of cardiac patients were reported higher concentration of K level serum. For diagnosis purposes K-level was directly associated with the cardiac disease progression. Conclusion: Hemodialysis patients with sudden cardiac arrest had reported very low concentrations of potassium levels. Dialysate prescriptions should be continuously reviewed and changed, especially after hospitalization in high-risk patients, to lower the risk of adverse cardiac events during hemodialysis. It was suggested that in the high-normal range of serum potassium seems to be safe and is linked to better outcomes. Keywords: Sudden cardiac arrest, Hemodialysis, serum potassium level, Hemoglobin

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