Background: Periodontitis has been associated to systemic diseases and this association could be due to an increase in circulating inflammatory and oxidative stress biomarkers in the periodontal disease. This study aimed to evaluate the relationship between inflammatory and pro-oxidant markers according to different stages of periodontitis. Methods: This cross-sectional study included 70 subjects who were divided into three groups according to periodontitis stage: stage II (n = 22), stage III (n = 30), and stage IV (n = 18). We evaluated periodontal parameters and levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen, and malondialdehyde (MDA) in serum, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine. Results: Serum hsCRP and fibrinogen levels were associated with periodontitis severity, which were higher in stage IV than in stages III and II of periodontitis (p = 0.003 and p = 0.025, respectively). We observed a slight yet insignificant increase in MDA levels related to periodontitis severity. Probing depth and clinical attachment loss were associated with serum fibrinogen and hsCRP levels. However, there were no significant associations between periodontal variables and MDA and 8-OHdG levels. Conclusion: Our data support an association between periodontitis and systemic inflammation, which increases with periodontal disease severity. This indicates the importance of the early diagnosis and treatment of periodontal disease to avoid the development or worsening of systemic inflammatory diseases.

Background:The aim of this study is to determine the changes in serum levels of malondialdehyde, 8-hydroxy-2'-deoxyguanosine, hsCRP and fibrinogen as indicators of oxidative stress and inflammatory markers, in response to non-surgical periodontal treatment. Case description:The patient, a 51-year-old male diagnosed with periodontitis was taken so as to be studied with a therapeutic objective, which should allow after three months the time of diagnosis and after non-surgical treatment. Topical doxycycline was used as adjunctive medication. Conclusion:A significant reduction in both serum levels of pro-inflammatory markers and oxidative stress indicators is observed after periodontal treatment.

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