A parasitic infestation is not only the fact that a multicellular organism is living inside another and developing at its expense, but also it is necessary to recognize that there are a large number of host-parasite interactions of intriguing complexity, which are articulated and converted into strategies of two sides in a continuous and interesting war. The study of some soluble and surface antigens of Ascaris, being an important part of the evasion or modulation immune response strategies, it is preponderant to understand the pathogenesis particularities of the parasite and the possible use of some of these antigens as therapeutic targets in the control of this disease and others as asthma, which keeps closeness in terms of the immune mechanisms that mediate them.