Several cities in developing countries are challenging the permanent process of urbanization. This generates a great disturbance on the hydrological response of the urbanized area during rainfall events, which can cause floods. Among the disturbances that urbanized basins may suffer, it is found that variations in rain losses (hydrological abstractions) can be estimated by the named volumetric runoff coefficient (CVOL) methodology. In the present study, this methodology is used in an attempt to estimate the hydrological abstraction of two nearby urbanized basins, with different degrees of impermeability, located in the city of Cuenca in Ecuador. The data for that analysis were collected between April and May of 2017. The results obtained indicate that the micro-basin with the largest impervious area presents the higher initial hydrological losses, the higher rate of decrease in abstractions, and the higher stormwater runoff flows per unit area. In addition, the abstractions found in the two urban micro-basins show great sensitivity to the maximum rainfall intensity and do not relate to the antecedent soil moisture. These results demonstrate the importance of having higher pervious surfaces in urbanized areas because they lead to reduce negative impacts associated with increased stormwater runoff on impervious surfaces.