Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Patient was investigated further for primary thyroid malignancy, and imaging revealed a nodule in the left lobe of thyroid. Neuroimaging showed osteolytic lesion involving the cranium.

Cardiac lesions are responsible for approximately 60-70% of sudden deaths. Histopathological examination of heart on autopsy plays an essential role in determining the cause of death.The present study was conducted to analyse histopathological spectrum of various cardiac lesions in autopsy specimens.This retrospective randomized study was conducted in the Department of Pathology, Pt. B. D. Sharma, PGIMS, Rohtak, Haryana. A total of 1152 autopsies were analysed, irrespective of cause of death. Among them heart was included in 1062 autopsies, out of which 62 were autolysed. Hence, 1000 specimen of whole heart were included in our study. A detailed gross and microscopic examination was done and histopathological findings were correlated clinically.Atherosclerosis was the most common cardiac lesion seen in 610 out of 1000 autopsied heart (61%), followed by ischaemic heart disease in 346 cases (34.6%). 27 cases had pericarditis, 23 cases revealed myocardial hypertrophy, 16 cases showed myocarditis, 11 cases had ventricular haemorrhage, 8 cases revealed changes of electrocution, 7 cases had tuberculosis, 6 cases had calcification of valve and 4 cases had metastasis from carcinoma. One case each of infective endocarditis, rheumatic heart disease and aortitis were also noted. The cause of death was not identified in 304 cases. Left anterior descending artery was most frequently involved vessels (35.02%) followed by left circumflex artery (33.41%) then right coronary artery (31.57%). Out of three major vessels 16.24% had single vessel involvement whereas 32.14% & 51.62% cases had two vessels and three vessels involvement respectively. Ischemic heart disease with coronary artery atherosclerosis was found to be the leading cause of death with triple vessel disease as the most common pattern of involvement.

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Background: Lung disorders spectrums include congestion, oedema, various inflammatory lesions, chronic obstructive pulmonary diseases and neoplastic lesions. The clinical and radiological findings in respiratory diseases are nonspecific and therefore a histopathological study is essential. Autopsies are necessary to establish cause of death of the person with help of antemortem history and investigations to rule out lung lesions. Aims and objectives were to identify the histopathological spectrum of lung disease and frequency of various lung pathologies in respect to age and sex.Methods: The retrospective study of 285 lung autopsy specimens received were fixed and processed. Routine paraffin sectioning was done followed by hematoxylene and eosin (H and E) staining. Relevant clinical and postmortem findings, gross and microscopic examination findings were recorded.Results: Most common lung pathology found was Edema and congestion in 149 cases (52.2%), pneumonia in 87 cases (30.5%) followed by tuberculosis in 33 cases (11.5%). Out of total 285 cases, 222 (77.9%) were males and 63 cases (22.2%) were females. The male to female ratio was 3.5:1. Maximum numbers of cases, in age group of 31-45 years were 108 cases (37.89%) followed by in age group 46-60 years were 90 cases (31.57%) followed by age group of 16-30 years 15.8%.Conclusions: Advances in diagnostic technology have not reduced the value of autopsy for the study and evaluation of the disease process. It has become crucial for adopting correct prophylactic actions for primordial and primary prevention of pulmonary dysfunctions.

Xanthogranulomatous epididymo-orchitis is an extremely rare diagnostic entity presenting as ascrotal mass with or without pain. Rarely, it can affect prostate, epididymis, and testicle. It canmimic a testicular malignancy both clinically as well as radiologically, hence, careful pathologicalexamination and biomarker study are essential to rule out malignancy. We report a case of 50 yearsold male with increasing right testicular swelling with a discharging pus. Skin over scrotum wasgangrenous. Right orchidectomy was performed. Histopathological diagnosis revealed features ofxanthogranulomatous epididymo-orchitis with no evidence of malignancy. IHC markers for tumorwere negative.