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Abstract. People spend most of their time at a few key locations, such as home and work. Being able to identify how the movements of people cluster around these "important places" is crucial for a range of technology and policy decisions in areas such as telecommunications and transportation infrastructure deployment. In this paper, we propose new techniques based on clustering and regression for analyzing anonymized cellular network data to identify generally important locations, and to discern semantically-meaningful locations such as home and work. Starting with temporally sparse and spatially coarse location information, we propose a new algorithm to identify important locations. We test this algortihm on arbitrary cellphone users, including those with low call rates, and find that we are within 3 miles of ground truth for 88% of volunteer users. Further, after locating home and work, we achieve commute distance estimates that are within 1 mile of equivalent estimates derived from government census data. Finally, we perform carbon footprint analyses on hundreds of thousands of anonymous users as an example of how our data and algorithms can form an accurate and efficient underpinning for policy and infrastructure studies.

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Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert elicitation is recommended. Overall, the application of quantitative WoE approaches hold promise to enhance the rigor, transparency and reproducibility for AOP WoE determinations and may play an important role in delineating areas where research would have the greatest impact on improving the overall confidence in the AOP.

Networks are critical to modern society, and a thorough understanding of how they behave is crucial to their efficient operation. Fortunately, data on networks is plentiful; by visualizing this data, it is possible to greatly improve our understanding. Our focus is on visualizing the data associated with a network and not on simply visualizing the structure of the network itself. We begin with three static network displays; two of these use geographical relationships, while the third is a matrix arrangement that gives equal emphasis to all network links. Static displays can be swamped with large amounts of data; hence we introduce directmanipulation techniques that permit the graphs to continue to reveal relationships in the context of much more data. In effect, the static displays are parameterized so that interesting views may easily be discovered interactively. The software to carry out this network visualization is called SeeNet.