No abstract

SR141716 blocked acute psychological and physiological effects of smoked marijuana without altering THC pharmacokinetics. These findings confirm, for the first time in humans, the central role of CB1 receptors in mediating the effects of marijuana.

Objective-To examine the eVects of four brands of commercially available moist snuV and non-tobacco mint "snuV" on plasma nicotine concentration, heart rate, blood pressure, and subjective measures. Intervention-Four brands of moist snuV and a non-tobacco mint snuV were tested. Subjects reported to the laboratory for five experimental sessions. After baseline measurement of dependent variables, each subject placed 2 g of one of the brands of snuV (or one Skoal Bandits pouch) between the cheek and gum for 30 minutes. The subjects remained in the experimental laboratory for an additional 60 minutes. Subjects-Ten volunteers who were daily users of smokeless tobacco. Main outcome measures-Plasma nicotine concentration, cardiovascular eVects, and subjective eVects. Results-Large amounts of nicotine were delivered rapidly to the bloodstream. The amount of nicotine absorbed and the rate of absorption were related to the pH of the snuV product in aqueous suspension. Cardiovascular and subjective eVects were related to the amount of nicotine absorbed. Conclusions-SnuV products are capable of rapidly delivering high doses of nicotine, which can lead to dependence. Long-term use of snuV can lead to a number of adverse health eVects including oral cancers, cardiovascular diseases, and gingival diseases. For these reasons, it is important that the public health community considers oral snuV use as a burden on public health in the same way that cigarette smoking is recognised. (Tobacco Control 1999;8:387-392)

No abstract

Our finding of attenuated nitric oxide-mediated vasodilation in response to methacholine and sodium nitroprusside in healthy black American men suggests that attenuated vasodilation in black subjects is a relatively generalized phenomenon, resulting in attenuated responses to multiple vasodilators that act through different receptor- and nonreceptor-mediated mechanisms.