Approximately 40% of the US population report using complementary and alternative medicine, including Maharishi Vedic Medicine (MVM), a traditional, comprehensive system of natural medicine, for relief from chronic and other disorders. Although many reports suggest health benefits from individual MVM techniques, reports on integrated holistic approaches are rare. This case series, designed to investigate the effectiveness of an integrated, multi-modality MVM program in an ideal clinical setting, describes the outcomes in four patients: one with sarcoidosis; one with Parkinson's disease; a third with renal hypertension; and a fourth with diabetes/essential hypertension/anxiety disorder. Standard symptom reports and objective markers of disease were evaluated before, during, and after the treatment period. Results suggested substantial improvements as indicated by reductions in major signs, symptoms, and use of conventional medications in the four patients during the 3-week in-residence treatment phase and continuing through the home follow-up program. Index Termscomplementary and alternative medicine; chronic disease; Maharishi Vedic Medicine; natural medicine Chronic diseases are a major public health problem in the United States. Currently, the prevalence of chronic diseases is about 40% in the US population with approximately 100 million Americans suffering from at least one chronic disorder. 1 This high prevalence raises concerns about the efficacy and limitations of conventional healthcare approaches in preventing and treating these disorders. 1,2 Such concerns may contribute to the increasing public and professional interest in alternatives to conventional modern medicine. Indeed, Eisenberg 2 reported that the use of unconventional or alternative therapies is widespread in the United States. For example, in 1990, approximately one third of the US population consulted alternative providers. These 425 million visits per year were more numerous than visits to primary care physicians. 2 Data from a 1997 report indicate even higher rates of complementary and alternative medicine utilization in the United States. 3 However, despiteFor further information, please address communiations to Jeremy Z. Fields, PhD., Center for Healthy Aging, Saint Joseph Hospital, 2900 N. Lake Shore Drive, Chicago IL 60657 (e-mail: jzfields@interaccess.com). This article reports a pilot study to investigate the potential clinical effectiveness of a comprehensive system of natural medicine, Maharishi Vedic Medicine (MVM), and examines the application of this approach when practiced as an intact multimodality system, as classically described. 7-9 Vedic medicine is reported to be the oldest continuously practiced medical system, having its heritage in the ancient Vedic civilization of India. 8,10-12 Vedic medicine, including Ayur-Veda, has been recognized by the World Health Organization as a sophisticated system of natural medicine with a detailed scientific literature comprising classical medical texts, an uninterrupted oral tra...