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Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus possess less potential for the side effects associated with MAO inhibition. The title compound (14) showed reduced in vivo myelotoxicity compared to linezolid in a 14-day safety study in rats, potent in vivo efficacy in murine systemic infection models, and excellent pharmacokinetic properties.

The imminent nanotechnology revolution promises dramatic advancements in science, technology, medicine and society as a whole. First generation products containing engineered nanoscale materials are already appearing in the marketplace, while more sophisticated products are being developed in laboratories around the world. Researchers and manufacturing employees are potentially exposed to dispersible nanoscale particulate matter via inhalation, ingestion and skin contact. Preliminary research indicates that in some cases nanoparticulate matter may be more toxic than other forms of the same or similar material. Application of the classical tools of occupational medicine and industrial hygiene is hampered by the lack of consensus guidelines for medical monitoring, exposure assessment, and exposure control.