Currently lymphoma is mainly treated with combination chemotherapy, hematopoietic stem cell transplantation, immunotherapy, and new targeted therapy, but treatment-related drug resistance, recurrence, extranodal and central infiltration, and leukemic transformation are still clinical problems that need to be solved urgently. Studies have shown that cytokines are expressed to varying degrees in lymphoma patients, which are significantly related to the progression of lymphoma, poor prognosis, chemotherapy response, and drug resistance. It has been confirmed that interleukin 6 (IL-6) and IL-10 are highly expressed in all types of lymphoma, and IL-10 is highly expressed in cerebrospinal fluid of central nervous system lymphoma, and both of them indicate poor prognosis. This review discusses the role of cytokines in the development and potential treatment of lymphoma.

A solution to the problem of database software portability and interchange has been achieved by the implementation of the Automated Information Management (AIM) system. AIM, a CODASYL-type database management system, is written entirely in a high-level industry-wide standard language. The technique of implementation is carefully designed to eliminate any machine dependencies such as word size or internal data representation. Thus, a program written using AIM will run on any machine supporting a commonly available subset of ANSI 1974 COBOL.The specifications of the Data Base Task Group, published in 1969 and 1971, and the later enhancements by the Data Definition Language Committee, published in 1973, have gained increasing acceptance by the data processing community. Although various computer manufacturers have introduced database management systems based on these proposals, each of these systems represent mutually noncompatible versions Of the standard. The approach taken in the development of AIM has overcome this problem and made CODASYL database facilities available to a broader class of machines than ever before.

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