[Purpose] Regenerative medicine and rehabilitation contribute in many ways to a specific plan of care based on a patient’s medical status. The intrinsic self-renewing, multipotent, regenerative, and immunosuppressive properties of mesenchymal stem cells offer great promise in the treatment of numerous autoimmune, degenerative, and graft-versus-host diseases, as well as tissue injuries. As such, mesenchymal stem cells represent a therapeutic fortune in regenerative medicine. The aim of this review is to discuss possibilities, limitations, and future clinical applications of mesenchymal stem cells. [Subjects and Methods] The authors have identified and discussed clinically and scientifically relevant articles from PubMed that have met the inclusion criteria. [Results] Direct treatment of muscle injuries, stroke, damaged peripheral nerves, and cartilage with mesenchymal stem cells has been demonstrated to be effective, with synergies seen between cellular and physical therapies. Over the past few years, several researchers, including us, have shown that there are certain limitations in the use of mesenchymal stem cells. Aging and spontaneous malignant transformation of mesenchymal stem cells significantly affect the functionality of these cells. [Conclusion] Definitive conclusions cannot be made by these studies because limited numbers of patients were included. Studies clarifying these results are expected in the near future.

Objective The aim of this study was to determine the influence of morphology on karate characteristics and basic motor skills for the criterion variable counter-punch (gyako zuki) in boys, after a two-year training program. Methods A system of 25 variables (12 morphological, 12 motor, and one situational (gyako zuki)) was applied in a sample of 82 karatists, aged 10 to 14 years. Data were processed using regression analysis. Results Body weight had a statistically significant influence on the criterion variable in the initial measurement, as well as on the triceps and back skinfolds in the final measurement. In the motor space, semi-squat endurance had a significant impact on both initial and final measurements. In the reduced system, triple jump, half-squat endurance, and long jump impacted the initial measurement, while the 30-second torso lift, hyperextension on the bench, and semi-squat endurance impacted the final measurement. Conclusion From the data obtained, it can be concluded that the counter-punch (gyako zuki) performance results were better in participants with higher body weight, longer arms, less subcutaneous upper arm and back fat, greater static and explosive power in the lower limbs, and greater hamstring and spine flexibility. Evidence Level II; Therapeutic Studies – Investigating the results.