The numerous bioactivities exhibited by tryptanthrins led chemists to develop synthetic approaches towards this important scaffold. In particular, conversion of isatins into tryptanthrins has been the subject of several studies. In this context, by using iodine and potassium hydroxide at room temperature, we have discovered a simple way to convert isatin and seven of its 5‐substituted derivatives (Bu, F, Cl, Br, I, OMe and OCF3) into the corresponding tryptanthrins. Furthermore, a mechanism was proposed to explain this original reactivity. Finally, we evaluated the antibacterial, antifungal, antioxidant and cytotoxic properties of the synthesized tryptanthrins. The unprecedented inhibition of human 20S constitutive proteasome was finally evaluated.

This paper focuses on promotional impulse buying. It aims at examining the impact of hedonic and utilitarian benefits of promotion on an impulse buying experience. The hypotheses were tested with a sample of 300 consumers doing their shopping in a hypermarket. Data were analyzed using binary logistic regression and structural equations. The results obtained allow us to confirm most of our hypotheses. The different outcomes of this research support the formulation of a number of theoretical, methodological and managerial recommendations.

International audienceVarious aromatic ketones were first functionalized next to the carbonyl function by deprotolithiation in the presence of a zinc salt followed by iodolysis. The outcome of the reactions was analyzed, and in particular their regioselectivity in the light of the calculated pKa values. The various halogenated ketones were next involved in copper-catalyzed two-fold C-N bond formation in order to obtain fused systems based on 2-aminopyrimidines. Besides potential antibacterial effect, reached 2-aminobenzothiopyrano[4,3,2-de]quinazoline proved to inhibit PIM1 (IC50: 0.61 μM) and CDK2/cyclin A (IC50: 2.0 μM) kinases

The measures of price image proposed by the literature are mostly multidimensional and fail to consider the richness of this concept. This study proposes a measure of price image. An exploratory and qualitative study helped generate a pool of items. Then the obtained list has been subject to a questionnaire-based survey in order to determine the dimensions that would better conceptualise price image in the context of purchasing cosmetic products and perfumes. Three dimensions have been identified: the dimensions of "price security", "proposed brand" and "value". These dimensions have been then compared to unveil the difference between a specialised store price image and a non-specialised store price image. A mean difference test is conducted to attest for the hypothesis that a non-specialised store price image is evaluated more positively than a specialised store price image. Our study is nonetheless limited. The implications and limitations of our study open up new research venues worth exploring.