The activity of intestinal disaccharidases, maltase trehalase, sucrase and lactase, was measured in five-sixths-nephrectomized uremic rats fed ad libitum and kept under conventional lighting conditions, with a dark night. In normal rats (controls), these disaccharidase activities changed with time of day, being high at night and low during daytime. In five-sixths-nephrectomized uremic rats, these disaccharidase activities were not as high at night and not as low during daytime as in controls, so their circadian variations were smaller than those of controls.

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