Purpose: The oral cavity Squamous Cell Carcinoma (OCSCC) involving infratemporal fossa (ITF) is considered as cT4b stage per AJCC 8th classification. The treatment of these group of patients is challenging due to the difficulty in achieving negative resection margin status. In this study we have highlighted our surgical technique with oncological outcome of enbloc resection of primary oral cancer involving ITF. Methodology: This was a single centre retrospective study which included only patients with OCSCC extending into ITF. Our surgical technique of systematic “out to in and top to bottom” approach was detailed. The perioperative outcomes, histopathological details, survival outcomes were measured. Results: Over the period of 1 year a total of 340 patients with OCSCC reported to our outpatient department, out of which 120 patients belonged to cT4 category and 32 patients were cT4b stage with involvement of ITF. Amongst 32 patients, 2 patients had distant metastasis and were excluded from the study. The 5 patients received neoadjuvant chemotherapy followed by surgery and rest all patients were taken up for upfront curative surgery. There were no significant intraoperative and postoperative complications. None of the margins were found to be involved or close in the final histopathology report. The median DFS and OS were 31 months and 27 months respectively at a median follow up of 29 months. Conclusion: Our systematic approach of enbloc resection of primary oral cancer involving ITF is safe and easily reproducible with high rate of negative resection margin status.

Lamellar ichthyosis (LI) is a rare genetic skin disorder that is present at birth, with an incidence of <1:300,000 in different parts of the world. However, there is little evidence of oral manifestations. Oral symptoms and oral rehabilitation of this condition are mostly unknown. This case report reiterates the need for proper dental diagnosis, treatment planning, and follow-up for a holistic approach. Here, we describe the oral manifestations and successful complete oral rehabilitation procedure performed in a 19-year-old female patient who had prediagnosed LI with skeletal class III jaw discrepancy due to maxillary deficiency.