AbstrakPeningkatan harapan hidup penderita thalassemia menyebabkan manifestasi penyakit pada berbagai organ, termasuk ginjal. Estimated glomerular filtration rate (eGFR) adalah penghitungan untuk mendeteksi gangguan dini fungsi ginjal, cara ini lebih dipercaya dibandingkan nilai kreatinin serum. The National Kidney Foundation merekomendasikan Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) untuk mengestimasi laju filtrasi glomerulus. Penelitian ini bertujuan mengetahui gambaran eGFR menurut CKD-EPI pasien thalassemia. Penelitian menggunakan metode deskriptif. Data diambil dari penderita thalassemia mayor rawat jalan di Klinik Hematologi Onkologi Medik, Rumah Dr. Sakit Hasan Sadikin Bandung, mulai 1 Februari sampai dengan 31 Maret 2016. Diperiksa kadar kreatinin serum dan penghitungan eGFR berdasar atas CKD-EPI. Dari 108 subjek penelitian, didapatkan usia rata-rata 18 tahun dengan jumlah wanita sebanyak 61,1 %. Gambaran eGFR berdasarkan CKD-EPI: menunjukkan hiperfiltrasi glomerulus pada mayoritas pasien dengan eGFR >120 mL/menit. Pemeriksaan fungsi ginjal pasien thalassemia diperlukan untuk memantau gangguan fungsi ginjal dan untuk pemilihan penggunaan jenis kelasi besi. Increased life expectancy of thalassemia patients has a consequence of various manifestations of the diseases in many organs including kidney. Estimated glomerular filtration rate (eGFR) can be used for detecting early renal dysfunctions due to the fact that this calculation is more accurate compared to creatinine serum measurement. The National Kidney Foundation recommends Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) for estimating GFR. The aim of this descriptive study was to describe eGFR profile based on CKD-EPI in thalassemia patients. Data were collected from ambulatory patients visiting the Hematology Oncology Medical Clinic of Dr. Hasan Sadikin General Hospital during the period of February 1, 2016 to March 31, 2016. Subjects were patients with thalassemia major. Creatinine serum level and calculated eGFR based on CKD-EPI were evakyated. One hundred and eightsubjects with a median age of 18 years participated in this study with 61.1% of them were female. According to the Kidney Disease Improving Global Outcomes ( KDIGO) 2012, the eGFR calculation based on CKD-EPI showed that the majority of patients experience glomerular hyperfiltration (eGFR >120 ml/mnt). In this study, most Thalassemia major patients showed glomerular hyperfiltration. Renal function test is needed to monitor renal function abnormalities and to choose the type of iron chelation therapy to be implemented. [MKB. 2016;49(1):22-7]

AbstrakPenggunaan tanaman herbal untuk pengobatan dan pencegahan penyakit semakin populer sehingga penelitian mengenai senyawa aktif dari tumbuhan yang berkhasiat semakin menjadi perhatian. Umbi sarang semut (Myrmecodia pendens) mengandung senyawa aktif berupa terpenoid, tanin, fenol, flavonoid, dan saponin yang memiliki efek antijamur pada Candida albicans. Penelitian ini bertujuan mengukur konsentrasi hambat minimum (KHM) dan konsentrasi bunuh minimum (KBM) fraksi air M. pendens dan menguji perbedaan efek antijamur antara fraksi air M. pendens dan nistatin pada C. albicans ATCC 10231. Penelitian dilaksanakan pada bulan Juni-Juli 2015 di Laboratorium Penelitian Jurusan Kimia Fakultas MIPA Universitas Padjadjaran. Penelitian ini menggunakan metode mikrodilusi dan nilai KHM diukur dengan enzyme linked immunosorbent assay reader dan nilai KBM diukur dengan pengujian pada media agar. Data dianalisis menggunakan uji-t dengan level signifikan p<0,05 untuk menentukkan perbedaan efek antijamur fraksi air M. pendens dengan nistatin pada C. albicans. Hasil penelitian menunjukkan bahwa nilai KHM ialah 1.250 μg/mL dan nilai KBM ialah 2.500 μg/mL. Simpulan penelitian ini ialah nilai KHM serta KBM fraksi air M. pendens ialah 1.250 dan 2.500 μg/mL dan terdapat perbedaan efek antijamur antara fraksi air dan nistatin terhadap C. albicans. The use of herbal plant for treatment and prevention of diseases is getting more popular, emphasizing the need for studies on active compounds from plants. Ant hill (Myrmecodia pendens) contains active compounds such as terpenoid, tannin, phenol, flavonoid, and saponin which have antifungal effects on Candida albicans. The objectives of the study were to measure the value of minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) of water fraction of M. pendens and antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. This study used microdilution and the effects were measured with enzyme linked immunosorbent assay reader to determine MIC value, followed by agar media assay to determine MFC. Data were analyzed using T test with significant level p < 0.05 to determine antifungal effect of water fractions of M. pendens against C. albicans compared to nystatin. The result showed that MIC value was 1.250 μg/ml and MFC value was 2.500 μg/ml. T test showed significant difference of % inhibition cells growth effect between M. pendens water fraction and nystatin (p=0.014 < 0.05). It is concluded that the M. pendens water fraction has an antifungal effect against C. albicans with MIC and MFC values of 1.250 and 2.500 μg/ml.There are differences in antifungal effects between water fraction of M. pendens and nystatin against C. albicans. [MKB. 2017;49(1):28-34]