Background: Obesity assessed by body mass index (BMI) and waist/hip ratio (WHR) are better predictors of cardiovascular disease. However, there is a dearth of data investigating the correlation of BMI and WHR with severity of CAD, particularly among the Indian population. This study aims to investigate the correlation of BMI and WHR with severity of CAD assessed by angiography.Methods: This open-label observational study included patients who underwent angiography, angioplasty, or coronary artery bypass grafting in the past one month. All data such as age, gender as well as anthropometric measurements such as height (meters), weight (kg), and waist circumferences (cm), and hip circumferences (cm) were collected at the first follow-up visit. BMI (kg/m2), body surface area (BSA) (m2), and WHR were calculated. Angiography findings were retrieved from the patient’s own record to note the severity of CAD.Results: In total, 302 patients were analyzed. The mean age of the study sample was 60.5±11.5 years, and 71.9% were males. Mean BMI, BSA, and WHR were 27.0±4.3 kg/m2, 1.3±0.8 m2 and 0.96±0.07, respectively. BMI was not significantly correlated with severity of CAD (p=0.051). In both male and female patients, WHR was not significantly correlated with severity of CAD (male: p=0.256 and female: p=0.851).Conclusions: It has been concluded that BMI and WHR were not significantly correlated with severity of CAD in an Indian population.

Three hundred and fifty biopsies from patients undergoing upper gastrointestinal endoscopy were studied for histopathological changes, H. pylori infection and argyrophilic nucleolar organizer region (AgNOR) counts. Histopathological examination revealed normal gastric mucosa in 10 (2.85%), gastritis in 254 (72.56%), intestinal metaplasia in 12 (4.0%), dysplasia in 13 (3.7%) and adenocarcinoma in 61 (17.4%). The mean (SD) AgNOR count was 1.66 (0.20) in normal, 2.43 (0.64) in gastritis, 3.09 (0.52) in intestinal metaplasia, 4.17 (0.31) in dysplasia, and 6.57 (0.98) in carcinoma. A statistically significant difference was observed between the AgNOR count of normal gastric mucosa and gastritis (p<0.001), gastritis and dysplasia (p<0.001), and dysplasia and adenocarcinoma (p<0.001). A statistically significant increase in mean AgNOR count was found with increase in H. pylori density in gastric biopsies (p<0.001) with gastritis. No significant difference was observed between mean AgNOR count of intestinal and diffuse type carcinomas. The AgNOR count in gastric biopsies with adenocarcinoma and H. pylori infection was 7.03 (0.85) as compared to 6.89 (0.73) in gastric biopsies with evidence of adenocarcinoma but without H. pylori infection. The difference was not statistically significant. The findings support the role of H. pylori as a promoting agent in gastric carcinogenesis by stimulating gastric epithelial cell proliferation at the stage of chronic inflammation, thereby making the cells more susceptible to endogenous or exogenous carcinogenic agents.

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Middle aortic syndrome is a rare vascular disorder threatening life beyond the age of 40 years. We describe a rare case of atypical presentation of middle aortic syndrome in a 35-year-old female, diagnosed in the third decade of life. The patient was successfully treated with stent implantation; however, she developed vision disturbance in her right eye.