Aim: To determine the circulatory procalcitonin levels, lipid profile and uric acid levels in patients presenting with preeclampsia and to correlate these with clinical severity of the disease. Methodology: This double blinded case-control study was conducted for two years in department of Obstetrics and Gynecology in collaboration with the department of biochemistry, Government Institute of Medical Sciences, Greater Noida, UP. This study included 80 subjects out of 40 were in group I (Control) and other 40 were in group II (PE patients) admitted in the hospital in third trimester of pregnancy. General demographic and clinical data such as age, gestational week, number of gestation, and BMI were recorded, and the results of routine blood cell counts, PCT and other indicators were also obtained. The PE patients were women younger than 40 years old who met the diagnostic criteria for PE in the guidelines for diagnosis and treatment of hypertensive diseases in pregnancy-2014. The healthy pregnant women were between 24 and 40 years old, with a single fetus, normal fetal development, normal liver and kidney function, and without eclampsia, gestational diabetes mellitus, fetal growth restriction, or history of other adverse pregnancy conditions.

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Background: Birth canal lacerations include the injuries to cervix, vagina or perineum. Those of the perineum often follow vaginal delivery, and most are first-and second-degree lacerations. Third- and fourth- degree lacerations are considered Obstetrical anal sphincter injuries (OASIS), and their combined incidence varies from 0.5-5%. Risk factors for these more complex perineal injuries have been studied. One important risk factor includes the length of the perineal body which plays an important role in determining the degree of perineal tears. The aim of the study was to assess the relationship between perineal body length and other characteristics, and occurrence of perineal lacerations during delivery in low risk primigravidae in an institution which advocates routine episiotomy for primigravidae.Methods: This was a prospective observational study carried out in the department of obstetrics and gynaecology at AJ Institute of medical sciences among primigravidae who met the selection criteria and delivered between September 2021 and November 2021. A total of 80 women were recruited in this study. In this study, we measured the perineal body length at rest, while the patient was in a dorsal lithotomy position during 1st stage of labor, after delivery the new born’s weight and head circumference were noted. The duration of second stage was noted. These parameters were studied in relation to the occurrence of perineal lacerations and the data was analysed.Results: In the present study it was noted that 10 participants (12.50%) had 3rd degree perineal tears and none had 4th degree perineal tears. With the perineal body length cut off of 3 cm, the sensitivity to predict 3rd and 4th degree perineal tears were found to be 80%, specificity of 90%, positive predictive value of 53.33% and a negative predictive value of 96.92%. The study concluded that a shorter perineal body length, was associated with the occurrence of a 3rd or 4th degree tear, p value of less than 0.00001. The study also showed increased incidence of higher degree perineal tears with higher birth weight and head circumference of the newborn with p value of 0.015 and 0.02 respectively.Conclusions: It can be concluded that Perineal body length of less than 3 cm, higher birth weight and head circumference is associated with an increased incidence of higher order perineal tears. Perineal body length hence has a good ability to predict the occurrence of perineal tears.

Background: Hypertensive disorders of pregnancy affect 6-8% of all pregnancies and along-with haemorrhage and infection, they form a complex triad, contributing immensely to maternal morbidity and mortality. Although exact aetio-pathogenesis of pre-eclampsia is unknown, multiple factors have been implicated to have a role in it; the factors being abnormal placental implantation, endothelial dysfunction, maternal immunological tolerance, cardiovascular, genetic, nutritional and environmental factors. Increased uric acid concentration is one of the most pronounced clinical findings in preeclampsia. Hyperuricemia in preeclamptic women is primarily due to a reduction in glomerular filtration rate due to endothelial dysfunction. In this study we look to explore the relationship between elevated serum uric acid and the perinatal outcomes, especially the ability to predict adverse perinatal outcomes.Methods: This was a hospital based retrospective study, conducted in A J institute of medical sciences and research centre, from January 2020 to December 2020. 75 study participants >20 weeks with diagnosed preeclampsia were chosen and their perinatal outcomes were measured. Chi square test and Fisher exact test was used to calculate p>0.05 was considered statistically significant. Results: Mean gestational age at delivery for elevated serum uric acid was 36.8 with SD=2.57 and those with normal uric acid levels is 38.43 with SD=0.89. FGR was seen in 5 patients, among which 4 (80%) had increased serum uric acid levels and 1 (20%) had normal serum uric acid levels. Total number of neonates who had APGAR score <7 was 3, among whom 2 neonates (66.66%) were born to increased uric acid level mothers. Out of 74 neonates, total number of neonates who had NICU admission were 20, among whom 9 neonates (45%) were born to mothers with increased serum uric acid levels.Conclusions: The study concluded that elevated serum uric acid is significantly associated with adverse perinatal outcomes, like FGR, low birthweight, low APGAR score and increased NICU admissions, there was no significant association between elevated serum uric acid level and mode of delivery.