Objective. This report is aimed at describing a rare clinical condition of advanced esophageal cancer with subcutaneous metastasis. Case Report. The present case refers to a patient diagnosed with stage IV esophageal squamous cell carcinoma which started with dysphonia and cervical nodules. Soon after that, the patient developed dysphagia and subcutaneous lesions on the right flank. Later in time, we documented a disease progression, with worsening of subcutaneous implants, lymph node, bone, and pulmonary metastases in addition to malignant hypercalcemia. Conclusion. This illustrates a rare presentation of an advanced esophageal neoplasm. Subcutaneous metastasis from internal malignancies is unusual, corresponding to less than 10% of cases. Its occurrence in patients with esophageal cancer is even less common with very few cases reported in literature.

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Introduction: The aim of this report is to describe a rare clinical situation in oncology, a gastric tumor with metastatic implants in subcutaneous tissue. This case demonstrates a rare scenario of gastric adenocarcinoma, with very few cases described in the literature, which evolved with subcutaneous metastases and whereby the role of systemic and even surgical treatment remains unclear. Case Report: The case reported refers to a patient with an advanced gastric adenocarcinoma that evolved with multiple metastases implanted in the subcutaneous tissue, in addition to peritoneal, non-regional lymph nodes, and bone involvement, requiring first-line chemotherapy treatment. Conclusion: This case manifests a rare presentation of advanced gastric neoplasm. The subcutaneous metastasis of internal malignancies is unusual, corresponding to less than 10% of neoplasms. The occurrence of skin or subcutaneous metastasis is still less usual in solid neoplasms, including gastric cancer, with a few cases reported in the literature. In this context, the role of diagnostic medicine is fundamental.

This report describes a rare case of malignant extraosseous giant cell tumor (GCT). It refers to a patient with an initial diagnosis of a locally advanced malignant GCT of the uterus, with disease progression to lung and mediastinum seven months after the diagnosis, requiring first line treatment with chemotherapy. Extraosseous presentation of GCT with early distant dissemination is unusual and the role of systemic cytotoxic treatment remains unclear.