The initial desertification in the Asian interior is thought to be one of the most prominent climate changes in the Northern Hemisphere during the Cenozoic era. But the dating of this transition is uncertain, partly because desert sediments are usually scattered, discontinuous and difficult to date. Here we report nearly continuous aeolian deposits covering the interval from 22 to 6.2 million years ago, on the basis of palaeomagnetic measurements and fossil evidence. A total of 231 visually definable aeolian layers occur as brownish loesses interbedded with reddish soils. This new evidence indicates that large source areas of aeolian dust and energetic winter monsoon winds to transport the material must have existed in the interior of Asia by the early Miocene epoch, at least 14 million years earlier than previously thought. Regional tectonic changes and ongoing global cooling are probable causes of these changes in aridity and circulation in Asia.

Hepatocellular carcinoma (HCC) is the predominant primary liver cancer in many countries and is the third most common cause of cancer-related death in the Asia-Pacific region. The incidence of HCC is higher in men and in those over 40 years old. In the Asia-Pacific region, chronic hepatitis B virus and hepatitis C virus infections are the main etiological agents; in particular, chronic hepatitis B infection (CHB) is still the major cause in all Asia-Pacific countries except for Japan. Over the past two decades, the incidence of HCC has remained stable in countries in the region except for Singapore and Hong Kong, where the incidence for both sexes is currently decreasing. Chronic hepatitis C infection (CHC) is an important cause of HCC in Japan, representing 70% of HCCs. Over the past several decades, the prevalence of CHC has been increasing in many Asia-Pacific countries, including Australia, New Zealand, and India. Despite advancements in treatment, HCC is still an important health problem because of the associated substantial mortality. An effective surveillance program could offer early diagnosis and hence better treatment options. Antiviral treatment for both CHB and CHC is effective in reducing the incidence of HCC.

The North China Craton (NCC) is a classical example of ancient destroyed cratons. Since the initiation of the North China Craton Destruction Project by the National Natural Science Foundation of China, numerous studies have been conducted on the timing, scale, and mechanism of this destruction through combined interdisciplinary research. Available data suggest that the destruction occurred mainly in the eastern NCC, whereas the western NCC was only locally modified. The sedimentation, magmatic activities and structural deformation after cratonization at ~1.8 Ga indicate that the NCC destruction took place in the Mesozoic with a peak age of ca 125 Ma. A global comparison suggests that most cratons on Earth are not destroyed, although they have commonly experienced lithospheric thinning; destruction is likely to occur only when the craton has been disturbed by oceanic subduction. The destruction of the NCC was coincident with globally active plate tectonics and high mantle temperatures during the Cretaceous. The subducted Pacific slab destabilized mantle convection beneath the eastern NCC, which resulted in cratonic destruction in the eastern NCC. Delamination and/or thermal-mechanical-chemical erosion resulted from the destabilization of mantle convection. timing, scale and mechanism, craton destruction, North China Craton Citation:Zhu R X, Chen L, Wu F Y, et al. Timing, scale and mechanism of the destruction