BACKGROUND AND AIM: Pathogenesis of COVID-19 -related headache is unknown, though the induction ofthe trigeminal neurons throughinflammation is proposed. Weaimed to investigatekey systemic circulating inflammatory moleculesand their clinical relations in COVID-19 patients with headache. METHODS: Thiscross-sectional study enrolled 88COVID-19 patients,hospitalized on a regular ward during the second wave of the pandemic.Clinical characteristics of COVID-19 patients were recorded,and laboratory testswere studied.RESULTS: The mean agesof 48 COVID-19 patients with headache (47.71±10.8) and 40 COVID-19 patients without headache (45.70±12.72) were comparable. COVID-19 patients suffered from headache had significantly higher serum levels of HMGB1, NLRP3, ACE2, and IL-6 than COVID-19 patients without headache, whereasCGRP and IL-10 levels were similar in the groups. Angiotensin II level was significantly decreased in the headache group.COVID-19 patients with headache showedan increased frequency of pulmonary involvement and increased D- dimer levels. Furthermore, COVID-19 was more frequently associated with weight loss, nausea, and diarrhea in patients with headache. The frequency of anosmia and ageusia did not reach significant levelsbetween the two groups. Serum NLRP3 levels were correlated with headache duration and hospital stay, while headache response to paracetamol was negatively correlated with HMGB1 and positively associated with IL-10 levels. CONCLUSION: Stronger inflammatory response is associated with headache in hospitalized COVID-19 patients with moderate disease severity.Increased levels of the circulating inflammatory and/or nociceptive molecules like HMGB1, NLRP3, and IL-6 may play a role in the potential induction of the trigeminalsystem and manifestation of headache secondary to SARS-CoV-2 infection.

186 GirişProksimal subklaviyan arterin tıkanıklığı veya darlığı nedeniyle vertebral arterden subklaviyan artere olan geri kan akımı subklaviyan çalma sendromu olarak adlandırılır.[1] Nabız ve kan basıncı etkilenen kolda daha düşük olarak bulunur. Klinik olarak her iki kol arasındaki kan basıncı farkı 20 mmHg'yi aştığı durumlarda subklaviyan çalma sendromundan şüphe edilebilir.[2] Semptomlar genellikle arka sisteme ait belirtiler olan diplopi, vertigo, bulantı, kusma, baş ağrısı veya kol iskemisinin neden olduğu kolda güçsüzlük ve ağrı şeklindendir. [3] Vertigo acil serviste en sık görülen şikayetler arasındadır ve genel toplu yetmezlik sebepleri arasında yeralan subklaviyan çalma sendromu da düşünülmelidir. Subklaviyan çalma sendromunda vertigo görülme oranı %52 olarak bildirilmiş-tir.[5] Vertigo genelde bulantı, kusma ve nistagmus ile birlikte görülmekte olup izole olgular nadirdir. [6] Bu yazıda, izole baş dönmesi şikâyeti ile acil servise başvuran ve ileri incelemelerle subklaviyan çalma sendromu tanısı konulan bir olgu sunuldu. SUMMARY Subclavian steal occurs when there is retrograde blood flow in the ver