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Objectives: To compare efficacy of azithromycin alone and in combination with ivermectin against the duration of novel corona virus symptoms. Study Design: Cross-sectional study. Setting: Shah Care Hospital, Peshawar. Period: April 5, 2020 to May 30, 2020. Material & Methods: Total patients included in the study were 100. Patients were divided into two groups by systematic random sampling: Group A: who received AZM (500mg once a day for 5 days), Group B: who received Ivermectin (12mg once a day for 5 days) and AZM (500mg once a day for 5 days). All the participants were informed to revisit hospital as soon as symptoms (at least two of the mentioned symptoms) like fever, fatigue, sore throat, cough, body aches/myalgia, anosmia/hyposmia, ageusia/hypogeusia and diarrhea disappears at least for 3 days (the actual day on which symptom(s) disappeared was noted). They were also advised to revisit hospital if they feel any inconvenience with the treatment or they notice worsening of the symptoms. The efficacy of the two regimens was based on the duration of disappearance of symptoms. RT-PCR was repeated after 15 days of the diagnosis and on day 21 who came positive on day 15. Results: In group A, the symptoms of 34% patients started to disappear during 3-5 days (mean±SD, 4.86 ± 0.42 days) following therapy, it disappeared during 6-8 days (7.18 ± 0.37) in 28% patients, 22% were symptom free during 9-10 days (10.12 ± 0.12), and 16% took ˃10 days to become symptom free (12 ± 0.26). Similarly, 52% of group B patient were relieved during 3-5 days (4.01 ± 0.32) of therapy, 36% were symptom free during 6-8 days (6.32 ± 0.14), symptoms of 8% disappeared during 9-10days (9.06 ± 0.25), and 4% took ˃10 days (11 ± 0.0) to become symptom free. Conclusion: Combination of ivermectin and azithromycin was more effective in making patients symptom free than azithromycin alone.

ABSTRACT… Objective: To evaluate the knowledge of prescriber's regarding antibiotics prescription in patients with chronic kidney and liver disease. Study design and technique: Cross-sectional study, convenient sampling. Setting: District Faisalabad of province Punjab, Pakistan. Period: 11 months. Material & Methods: Total 250 prescribers were approached, among which 210 prescribers responded and filled the questionnaire. Data after collection was divided into two categories: (i) on the basis of area of practice of the prescribers (urban & rural) and (ii) on the basis of qualification of the prescribers (consultants, postgraduate residents, general practitioners & paramedics). Results: The results of the current study revealed that knowledge of the prescribers of urban area was better as compare to the prescribers of rural area with significant difference of 0.001. Similarly a significant difference of 0.001 was found between the knowledge of consultants, postgraduate medical residents, general practitioners and paramedics. Consultants were found to be the most knowledgeable prescribers while paramedics were the least. Conclusion: Prescribers who were practicing in urban areas and the ones who were more qualified (consultants) have sound knowledge of prescribing antibiotics in patients of chronic kidney and liver disease. Keywords:Antibiotic, Chronic kidney disease, Chronic hepatic disease, Glomerular filtration rate, Bioavailibility

ABSTRACT… Objective:To compare the levels of creatine kinase-MB in male and female patients of acute myocardial infarction before and after the treatment. Study design: Comparative study. Setting: Faisalabad Institute of Cardiology, Faisalabad, Pakistan. Period: 08 months, March 2014 to September 2014. Material & Methods: Total 60 patients of acute myocardial infarction were enrolled in the study; 30 males and 30 females. The creatine kinase-MB levels of all the patients were checked and compared before starting the treatment for acute myocardial infarction and then after 24 &48 hours of treatment. Results: The results of the study shown that the mean of CK-MB levels before treatment was high in male as compared to female patients with p-value < 0.01. Similarly the comparison of mean CK-MB levels after 24 and 48 hours of treatment were also found to be significantly higher in male patients with p-value <0.01 each. Conclusion: The levels of CK-MB in male acute myocardial infarct patients were high both before and after the treatment. Key words:Myocardial infarction, Creatine kinase-MB, Cardiovascular diseases, Troponin, Electrocardiogram, Cardiac biomarkers

Introduction: A rigorous characterization of the impact of residential status of medical students (hostelites vs. day scholars) on the particulars of their academic performance has been lacking in Pakistan. Objective: To determine the relation of residential status of third year MBBS students to their academic performance in Forensic Medicine based on comparison of their pre-professional and professional examinations results during 2019. Materials & Methods: A comparative study was conducted from August to October 2019 on the examination performance of third year MBBS students of Rehman Medical College, Peshawar in the subject of Forensic Medicine. The results of theory and viva pre-professional and professional examinations were compared and categorized by residential status of students (Hostelites or Day Scholars). Students were categorized into groups according to their academic performance. Descriptive and Comparative data analysis was performed by SPSS 22.0, keeping p≤0.05 as significant. Results: No significant difference was found in the mean marks of hostelites and day scholars in pre-professional and professional examinations. The trend of significant improvement from pre-professional to professional examinations was similar in both groups, and it applied to both the theory and viva examinations. A significant correlation existed between the performance in two examinations among all students with no difference between the hostelites and day scholars. Conclusion: Residential status of MBBS students had no effect on their academic performance in the subject of Forensic Medicine. Keywords: Academic performance, Forensic Medicine, hostelites, day scholars