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Interventions: 40 patients received 2 doses of 60 mg Duloxetine (2 hours before surgery and 24 hours after surgery) and 37 patients received placebo. The quality of Recovery 40 (QoR 40) questionnaire forms were completed by the participants 12 hours after surgery. Questionnaire scores, opioid analgesic use and length of hospital stay were compared between the study groups. Measurements/Results: Patient characteristics (age, BMI, ASA score, operation time, estimated blood loss) of the study groups were comparable. The total QoR 40 scores were not significantly different between the groups (p = .91) 24 hours after surgery. Postoperative narcotic analgesic use and hospitalisation length were not significantly different between groups. Conclusions: Duloxetine does not improve the quality of recovery scores and narcotic analgesic use in patients undergoing laparoscopic hysterectomy for benign conditions.

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