Three di-, (Gly),, (Val), and (Leu),, and one tetra-peptide, (Gly),, have been acylated with 2-chloroacetyl chloride and the resulting products treated with Cs2C03 in dimethylformamide (DMF) solution; (Gly), and (Leu), provided strained 9-membered rings whereas (Val), dimerized to the 18-membered ring.
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