significantly associated with age, weaning status and GCS of the patient (p < 0.05). Patients with lower GCS had higher chances of reintubation. Reintubation was not associated with sex, operation status and time of extubation. Conclusion: The rate of unwanted extubations and subsequent reintubations in Neuro ICU, can be decreased with protocol based monitoring, and through well maintained registers by neuro nurses. The knowledge of determinants of self extubation and the predictive factors of reintubation can be used as an effective tool by Nurses, for the prevention of self extubation and accompanying complications. Study/Objective: The main objective of this study was to assess knowledge and skills in caring for life-threatening arrhythmias among nurses working in critical care settings at Muhimbili National Hospital (MNH). Specific Objectives: 1. To determine the level of knowledge among nurses regarding caring for life-threatening arrhythmias in critical care settings at MNH. 2. To recognize skills of nurses regarding caring for life-threatening arrhythmias in critical care settings at MNH. 3. To identify barriers to acquiring higher knowledge and skills in caring for life-threatening arrhythmias among nurses in critical care settings at MNH. Background: Life-threatening arrhythmias, if not intervened immediately, can cost a patient's life. There is no clear understanding on the nurse's knowledge and skill level in the areas of life-threatening arrhythmias, caring, and arrhythmia identification at Muhimbili National Hospital (MNH). Meanwhile, the intensity of barriers met by nurses on achieving higher levels of knowledge and skills in developing countries, including Tanzania, are significantly not analyzed. The aim of this study was to assess knowledge and skills in caring for life-threatening arrhythmias among nurses working in critical care settings at MNH. Methods: A descriptive, cross-sectional study design was used while a convenience sampling method was employed. Data were analyzed by using SPSS Version 20.0. Results were presented in frequencies and percentages and presented using figures, tables, and text. Results: The majority of the participants (60%) were identified as having high knowledge, while observational skills in caring for life-threatening arrhythmias among study participants was generally poor (15.6%). The most barriers identified in acquiring higher knowledge and skill was stress caused by overwhelming workload (68.8%). Conclusion: The study revealed that nurses have a high knowledge level; however, the observational skills were low in caring for patients with life-threatening arrhythmias. A high level of knowledge might be due to training performed; yet skills were low due to minimal usage of available equipment or guidelines. 1. Disaster Management, bezmialem vakif university, istanbul/Turkey 2. Dİsaster Medİcİne Doctorate Programme, BEZMİALEM VAKİF UNİVERSİTY INSTITUTİON OF HEALTH SCİENCES, ISTANBUL/Turkey 3. Nursİng Department, BEZMİALEM VAKİF UNİVERSİTY FACULTY OF HEALTH SCİENCES,...