The tyrosine kinase receptor protein c-kit exerts a broad range of activities during organogenesis and normal cell development. It is involved in the development of multiple haematopoietic cell lines, mast cells, melanogenesis, interstitial cells of Cajal and gametogenesis. Recent studies have revealed that over-expression of c-kit protein occurs in a narrow subset of malignant neoplasms, including gastrointestinal stromal tumors, myeloid leukemias, seminomas and adenoid cystic carcinomas (ACC). C-kit reportedly is not expressed in polymorphous low-grade adenocarcinoma (PLGA).We examined the expression of the c-kit antigen in the malignant salivary gland neoplasms ACC and PLGA and compared it to its expression in the benign salivary gland tumor monomorphic adenoma (including trabecular adenoma, canalicular adenoma and basal cell adenoma). Formalin-fixed paraffin-embedded sections of 49 salivary gland neoplasms (17 monomorphic adenomas, 17 PLGA and 15 ACC) accessioned between 1989 and 2002 were retrieved from the files of the

Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.

Objectives:The purpose of this study was to compare the extent of p63 immunoreactivity in the malignant salivary gland neoplasms adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) and to compare it to the expression of this marker in the benign salivary gland tumor monomorphic adenoma (including canalicular adenoma and basal cell adenoma).