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Multiple congenital malformations occurred in kittens of three cats treated orally at weekly intervals with 500-1000 mg of the antifungal drug griseofulin. Malformations of the brain included exencephaly, malformed prosencephalon, caudal displacement, and hydrocephalus. Skeletal malformations included cranium bifidium, spina bifida (C1 through C4, and sacral), abnormal atlantooccipital articulation, cleft palate, absence of maxillae, and lack of tail vertebrae. Cyclopia and anophthalmia with absence of optic nerves and rudimentary optic tracts were also observed. Atresia ani, atresia coli, lack of atrioventricular valves in the heart, and absence of external nares and soft palate were other abnormalities present.

The linear decomposition rates for the decomposition reactions "$3 -+ NH3 + HCI and CuSO!.3H10 -CuS04.HzO are interpreted on the basis of a modified Langmuir-Hinshelwood bimolecular surface reaction mechanism. An absolute rate treatment (similar in method to that developed by Laidler, Glasstone and Eyring for heterogeneous processes) accounts for the unusually low reaction probabilities per collision of gaseous product molecules with the reaction interface in terms of interference by a physically adsorbed product layer.Active nitrogen was obtained from nitrogen and ammonia in roughly equal amounts when these gases were subjected to a condensed electrical discharge under com arable conditions. Nitric oxide gave a smaller yield of active nitrogen, probably owing to consumption of active nitrogen gy reaction with the parent gas. The behavior suggests that all three gases were almost completely dissociated in the discharge tube to yield nitrogen atoms as the main reactive component of active nitrogen. However, variation of the voltage across a nitrogen discharge indicated that a second species was probably also present in considerable amounts.