Out of a total of 2272 diurnal curves (DC) of intraocular pressure (IOP) obtained from 1178 patients 690 first curves of the right eye of all patients were analysed. For each DC there were 4-6 IOP readings taken between 8 am and 6.30 pm of the same day. The patients' diagnosis, age, sex, type of IOP lowering medication, diabetes, and the calendar month of the year were recorded. In 40% of cases the highest IOP was found at the earliest morning measurement with some 65% of peaks occurring before noon. The lowest IOP measurement showed no specific predilection for any particular time of the day.

A population-based study found an overall incidence rate of symptomatic retinal vein occulusion (RVO) in a 4-year period to be 2.14 per 1,000 in the 40 years and over age group. When cases found among glaucoma clinic patients were separated from the remainder of the population there was marked difference in the incidence rate of RVO in the same time period (1.85 and 17.3 per 1,000, respectively). The rate of RVO increased significantly (p < 0.001) with age in the general population from 0.93 per 1,000 among persons under 64 years of age to 5.36 per 1,000 among persons over 65. The increase in the rate of RVO by age was less dramatic in the glaucoma clinic population. The two populations also differed in the frequency of the occlusion type: the ratio of the rate of branch vein occlusion to central vein occlusion was 3.2:1 in the general population, but equally distributed in the glaucoma clinic population. Persons with increased intraocular pressure and/or glaucoma were found to have a higher prevalence of RVO than persons with no history of elevated intraocular pressure.

Oral administration of ACU-4429 produced a dose-dependent inhibition of the b-wave of the electroretinograms, was well tolerated up to 75 mg, and demonstrated linear pharmacokinetics across doses.

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