ESCA measurements on a series of gold compounds reveal a monotonic relationship between binding energies of the Au 4f levels and formal oxidation states, and provides first evidence for the oxidation state -1 of gold in CsAu and RbAu.

The synthesis of new N‐carbamoyl‐substituted isoxazolidine‐4,5‐diols and their 4,5‐anhydro analogues, isoxazolidinyl epoxides, is described. The 4,5‐unsubstituted 2,3‐dihydroisoxazole starting materials reacted directly with potassium osmate/4‐methylmorpholine N‐oxide and 3,3‐dimethyldioxirane, respectively. All addition reactions proceeded with excellent anti selectivity with respect to the substituent at C‐3. The obtained isoxazolidinyl epoxides as well as benzoylated isoxazolidine‐4,5‐diols were subjected to nucleophilic substitution reactions with various nucleophiles. 4‐Hydroxyisoxazolidines with chlorine, methoxy, and azide substituents bound to C‐5 were prepared in moderate to good yields. In terms of chemical stability, the discussed isoxazolidinyl epoxides can be isolated and stored for a long time.

The extent of interactions with various biomolecules is a crucial feature of newly developed metallodrugs, worthy of thorough investigation, as its understanding helps uncover the fate of these xenobiotics in...

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