No abstract

electrostatic binding to a DNA phosphate group. Loss of correlation found with the parameters associated with the diamino side chain in series III when series I and III were combined suggests that perhaps different substitu-ents at position 7 dictate different drug-DNA orientations which therein alter the manner in which the 4-diamino side chain is able to interact with the DNA backbone.Antimalarials. 7-Chloro-4-(substituted amino)quinolines

from EtOH and dioxane to give 1.8 g (64%) of 16 as reddish gray needles, mp 210°dec.The 3-Me analog 17 and the 5-(5-nltro-2-furylacrylidene-1 hiazolidene-2,4-diones 21-25 were prepd similarly.5-(2-Furylidene)-2-methylrhodanine ( 27).soln of 3.0 g (0.02 mole) of 3-methylrhodanine, 2.0 g (0.02 mole) of furfural, and 0.5 ml of piperidine was heated under reflux in 30 ml of 95% EtOH for 30 min. The cryst which formed on cooling were collected, dried, and recrystd from 95% EtOH to give 4.25 g (95% ) of 27 as long golden yellow needles, mp 142-143°.5-(2-Furylidene)rhodanine ( 26) and the thiazolidine-2,4-diones 28 and 29 were prepd similarly.5-(2-Furylacryliderte)thiazolidene-2,4-dione (31). A mixt of 1.2 g (0.01 mole) of thiazolidine-2,4-dione, 1.2 g (0.01 mole) of Singh, ct a/.2-furylacrolein, and 0.5 ml of piperidine in 30 ml of 95% EtOH was refluxed for 1 hr. The mixt was allowed to cool overnight causing the pptn of a yellow solid which was collected, dried, and recrystd from EtOH and dioxane to give 1.5 g (71 % ) 30 as reddish brown needles, mp 217-218°. MD-2869 and is Contribution No. 887 from the Army Research Program on Malaria.

No abstract

Enclosed beaches along urban coastlines are frequent hot spots of fecal indicator bacteria (FIB) pollution. In this paper we present field measurements and modeling studies aimed at evaluating the impact of small storm drains on FIB pollution at enclosed beaches in Newport Bay, the second largest tidal embayment in Southern California. Our results suggest that small drains have a disproportionate impact on enclosed beach water quality for five reasons: (1) dry weather surface flows (primarily from overirrigation of lawns and ornamental plants) harbor FIB at concentrations exceeding recreational water quality criteria; (2) small drains can trap dry weather runoff during high tide, and then release it in a bolus during the falling tide when drainpipe outlets are exposed; (3) nearshore turbulence is low (turbulent diffusivities approximately 10 −3 m 2 s −1 ), limiting dilution of FIB and other runoffassociated pollutants once they enter the bay; (4) once in the bay, runoff can form buoyant plumes that further limit vertical mixing and dilution; and (5) local winds can force buoyant runoff plumes back against the shoreline, where water depth is minimal and human contact likely. Outdoor water conservation and urban retrofits that minimize the volume of dry and wet weather runoff entering the local storm drain system may be the best option for improving beach water quality in Newport Bay and other urban-impacted enclosed beaches.