Spin-lattice relaxation times were observed for protons in a number of aqueous solutions of symmetrical chromium (III) complexes. The observed times were in the order to be expected if it is assumed that those ions displaying the greatest tendency to interact with solvent water also exhibit the greatest relaxation effect. Thus, relaxation times for protons in solutions of the ions Cr(H2O)6+3, CrF6—3, Cr(NH3)6+3, Cr(C2O4)—3, Cr(en)3—3, and Cr(CN)3—3 were observed to increase in the order given.

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Thrombocytopenia is defined as a decrease in the platelet count to less than 100 x 10(9)/L and it is the most commonly reported drug-induced blood dyscrasia. Heparin is the most commonly reported cause of drug-induced thrombocytopenia with a reported incidence between one and ten percent. Thrombocytopenia induced by cephalosporins has been reported but is relatively rare. This report does not completely document that two third-generation cephalosporins caused platelet counts to fall less than 100 x 10(9)/L in the patient described but there was no other explanation available. Platelet counts began to fall with the institution of third-generation cephalosporins and began to rise when these agents were stopped. In order to document that thrombocytopenia was induced by the third-generation cephalosporins a rechallenge would have been necessary; this was not considered to be safe in this patient. A review of the literature is presented describing similar cases of cephalosporin-induced thrombocytopenia.

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