The effects of two chemically different diuretic agents, hydrochlorothiazide and metolazone, a new quinethazone derivative, were studied in a group of 21 hypertensive patients. A change‐over, double‐blind design was used for 50 mg. of hydrochlorothiazide, 2.5 mg. of metolazone, and 5.0 mg. of metolazone. Body weight, blood pressure, blood urea nitrogen, electrolytes, uric acid, and blood sugar one hour after carbohydrate load were the measurements used to examine the efficacy of the drugs. Blood counts and serum glutamic oxalacetic transaminase also were monitored. The results showed no differences among the three treatments, but all showed the same significant response when compared to placebo for all measurements, except for blood counts, serum glutamic oxalacetic transaminase, and blood sugar.

larger than the trachea in its nondistended state.We effect simple and rapid in¬ flation by first aspirating air from the cuff with a 10 cc syringe. The cuff is then over-distended with sal¬

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