The prevalence of unique, disparate satellite command and control (SATC2) systems in current satellite operations is problematic. As such, the United States Air Force aims to consolidate SATC2 systems into an enterprise solution that utilizes a common Human–Machine Interface (HMI). We employed a User-Centered Design (UCD) approach including a variety of methods from design thinking and human factors engineering to develop a solution that is effective, efficient, and meets operator needs. During a summative test event, we found that users had significantly higher situation awareness, lower workload, and higher subjective usability while using the HMI developed via UCD over the existing, or legacy, HMI. This case study serves as evidence to support the assertion that involving users early and often has positive and tangible effects on the development of aerospace systems.