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Intranuclear annulate lamellae were initially observed on day 9 of gestation. They increased in frequency until day 12, after which a decline in frequency was noted. Numerous IAL were in close association with nucleoli on days 11 and 12 and numerous large dilatations of the intermembranous space were present. IAL were also associated with cytoplasmic invaginations and inclusions of the nucleus. The frequency of invaginations and inclusions also increased from day 9 to 12 and brought increased amounts of cytoplasm into contact with the nucleus. Continuity of the intermembranous space of the IAL with the perinuclear space and the latter with the cisterns of rough endoplasmic reticulum suggested a possible route for nuclear-cytoplasmic exchange in either direction.

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