Meniscal T1(rho) and T2 values correlate with clinical findings of OA and can be used to differentiate healthy subjects from patients with mild or severe OA.
(1) To assess the degree of focal cartilage abnormalities in physically active and sedentary healthy subjects as well as in patients with early osteoarthritis (OA). (2) To determine the diagnostic value of T2 and T1rho measurements in identifying asymptomatic physically active subjects with focal cartilage lesions. Thirteen asymptomatic physically active subjects, 7 asymptomatic sedentary subjects, and 17 patients with mild OA underwent 3.0-T MRI of the knee joint. T1rho and T2 values, cartilage volume and thickness, as well as the WORMS scores were obtained. Nine out of 13 active healthy subjects had focal cartilage abnormalities. T1rho and T2 values in active subjects with and without focal cartilage abnormalities differed significantly (p < 0.05). T1rho and T2 values were significantly higher (p < 0.05) in early OA patients compared to healthy subjects. T1rho measurements were superior to T2 in differentiating OA patients from healthy subjects, yet T1rho was moderately age-dependent. (1) Active subjects showed a high prevalence of focal cartilage abnormalities and (2) active subjects with and without focal cartilage abnormalities had different T1rho and T2 composition of cartilage. Thus, T1rho and T2 could be a parameter suited to identify active healthy subjects at higher risk for developing cartilage pathology.
Objective. To use a combination of magnetic resonance diffusion-tensor imaging (MR-DTI) and MR imaging of voxel-based morphometry (MR-VBMFibromyalgia syndrome (FMS) belongs to a group of common functional somatic syndromes that are characterized by chronic widespread pain and are often accompanied by functional disturbance (dizziness, vertigo, palpitations, and peripheral edema) in different organ systems and symptoms of sleep disturbance, anxiety, memory problems, fatigue, and exhaustion. Because of the association between FMS development and severe organic illness, accidents, or stressful life events, FMS has also been regarded as a stress-related disorder (1). The combination of chronic widespread pain, sleep disturbance, and pronounced and ongoing stress symptoms is highly disabling, yet there is no universally effective treatment, and the pathophysiologic features of FMS are incompletely understood. Although this disorder has frequently been described as musculoskeletal or Supported by funds from the Departments of Anaesthesiology and Radiology, Klinikum Grosshadern, Ludwig-Maximilians University.
Reduced FA and RA values in patients with AD suggest that diffusion-tensor imaging of the brain can be used to confirm clinical manifestation of AD but is less applicable in the detection of MCI.
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