A B S T R A C19S serum fractions with anti-YE antibody activity did not release histamine from normal human peripheral blood leukocytes, whereas specific rabbit anti-yE antisera consistently induced leukocytic histamine release. Moreover, macroglobulin fractions with anti-yE activity did not block allergen-specific leukocyte histamine release induced by in vitro leukocyte challenge with allergens such as Bermuda grass and leukocytes from allergic donors. In some instances 19S human serum
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