Photoacoustic computed tomography (PACT) is a rapidly emerging bioimaging modality that seeks to reconstruct an estimate of the absorbed optical energy density within an object. Conventional PACT image reconstruction methods assume a constant speed-of-sound (SOS), which can result in image artifacts when acoustic aberrations are significant. It has been demonstrated that incorporating knowledge of an object’s SOS distribution into a PACT image reconstruction method can improve image quality. However, in many cases, the SOS distribution cannot be accurately and/or conveniently estimated prior to the PACT experiment. Because variations in the SOS distribution induce aberrations in the measured photoacoustic wavefields, certain information regarding an object’s SOS distribution is encoded in the PACT measurement data. Based on this observation, a joint reconstruction (JR) problem has been proposed in which the SOS distribution is concurrently estimated along with the sought-after absorbed optical energy density from the photoacoustic measurement data. A broad understanding of the extent to which the JR problem can be accurately and reliably solved has not been reported. In this work, a series of numerical experiments is described that elucidate some important properties of the JR problem that pertain to its practical feasibility. To accomplish this, an optimization-based formulation of the JR problem is developed that yields a non-linear iterative algorithm that alternatively updates the two image estimates. Heuristic analytic insights into the reconstruction problem are also provided. These results confirm the ill-conditioned nature of the joint reconstruction problem that will present significant challenges for practical applications.

Abstract. We report an investigation of image reconstruction in photoacoustic tomography for objects that possess heterogeneous material and acoustic attenuation distributions. When the object contains materials, such as bone and soft-tissue, that are modeled using power law attenuation models with distinct exponents, we demonstrate that the effects of acoustic attenuation due to the most strongly attenuating material can be compensated for if the attenuation of the other less attenuating material(s) are neglected. Experiments with phantom objects are presented to validated our findings.

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is an emerging computed biomedical imaging modality that exploits optical contrast and ultrasonic detection principles. Iterative image reconstruction algorithms that are based on discrete imaging models are actively being developed for OAT due to their ability to improve image quality by incorporating accurate models of the imaging physics, instrument response, and measurement noise. In this work, we investigate the use of discrete imaging models based on Kaiser-Bessel window functions for iterative image reconstruction in OAT. A closed-form expression for the pressure produced by a Kaiser-Bessel function is calculated, which facilitates accurate computation of the system matrix. Computer-simulation and experimental studies are employed to demonstrate the potential advantages of Kaiser-Bessel function-based iterative image reconstruction in OAT.

Abstract:The state of polarization of strongly focused, radially polarized electromagnetic fields is examined. It is found that several types of polarization singularities exist. Their relationship is investigated, and it is demonstrated that on smoothly varying a system parameter, such as the aperture angle of the lens, different polarization singularities can annihilate each other. For example, the evolution of a lemon into a monstar and its subsequent annihilation with a star is studied. Also, the quite rare collision of a C-line and an L -line, resulting in a V -point, is observed.

Transport-of-intensity and transport-of-spectrum equations are derived using the coherent mode decomposition for paraxial fields having an arbitrary state of coherence. We give a simple example that demonstrates the difference between a partially coherent and a fully coherent transport of intensity or spectrum. The results presented here may be used to estimate the intensity response in a variety of phase-contrast imaging modalities and may form the basis for improved phase-retrieval techniques.