O conhecimento do perfil epidemiológico das intoxicações medicamentosas é um importante guia para a gestão de recursos destinados ao planejamento e à implementação de ações que previnam a ocorrência desse agravo. O presente trabalho buscou estudar o perfil das intoxicações medicamentosas ocorridas no município de Primavera do Leste-MT, entre 2007 a 2014. Foram avaliados dados secundários registrados no Sistema de Informação de Agravos de Notificação (SINAN), que permitiram a realização de um estudo epidemiológico descritivo e transversal em que se analisaram informações referentes ao perfil das vítimas (idade, sexo) e dos casos (circunstâncias, tipo de exposição e evolução dos casos). Registraram-se 52 casos, destes 73,1% (n=38) são vítimas do gênero feminino e 26,9% (n=14) do masculino. As intoxicações com medicamentos ocorreram em quase todas as faixas etárias (01 a 64 anos), porém a maioria das vítimas possuía entre 20 a 39 anos (n=26; 50%) e 15 a 19 (17,3%; n=9). As circunstâncias relacionadas às intoxicações foram: 73,1% (n=38) por tentativa de suicídio, 15,4% (n=8) por uso acidental e os demais pelo uso habitual, abuso, automedicação e violência/homicídio. Em 82,7% (n= 43) dos casos, as exposições foram agudas e únicas, em 9,6% (n=5) agudas repetidas, não sendo registrada exposição crônica. 84,6% (n= 44) das intoxicações evoluíram para cura sem sequelas. Registrou-se um óbito em função da tentativa de suicídio. As intoxicações por medicamentos são frequentes e representam um importante problema de saúde pública, que necessita de ações preventivas e educativas com foco nas vítimas e circunstâncias mais frequentes. Palavras-chave: Suicídio. Abuso de Medicamentos. Automedicação. AbstractKnowledge of the epidemiological profile of drug intoxications (Notification of Injury Information System) is an important guide for the resources management  intended to the planning and implementation of actions that prevent the occurrence of this outcome. The present study aimed to describe the drug intoxications profile occurring in the municipality of Primavera do Leste -MT, between 2007 and 2014. Secondary data recorded in  SINAN (Information System for Notifiable Diseases) were used to conduct a descriptive and cross - sectional epidemiological study in which information was analyzed regarding the victims’ profile (age, sex) and cases (circumstances, type of exposure and evolution of cases). There were 52 cases, of which 73.1% (n = 38) were females and 26.9% (n = 14) males. Drug intoxications occurred in almost all age groups (01 to 64 years), but the most of the  were between 20 and 39 years (n = 26; 50%) and 15 to 19 (17.3%; n = 9). The circumstances related to intoxication were: 73.1% (n = 38) for attempted suicide, 15.4% (n = 8) for accidental use and the others for habitual use, abuse, self-medication and violence / homicide. In 82.7% (n = 43) of the cases the exposures were acute and single, in 9.6% (n = 5) repeated acute, and chronic exposure was not recorded. 84.6% (n = 44) of intoxications evolved to cure without sequelae. A death was recorded due to suicide attempt. Drugs intoxications are frequent and represent a relevant public health problem that requires preventive and educational actions with a focus on the most frequent victims and circumstances. Keywords: Suicide. Drug Misuse.Self-Medication.

A resistência aos antimicrobianos por micro-organismos patogênicos é consequência, principalmente, do uso irracional de antibióticos e constitui uma ameaça para o controle das doenças infecciosas. Estudos das atividades antibacterianas de extratos de plantas podem fornecer alternativas para o tratamento antimicrobiano e, por isso têm despertado interesse pela investigação para o potencial da flora brasileira. Objetivou-se analisar a possível atividade antibacteriana da espécie Qualea parviflora Mart. (Pau-terra). Os ensaios foram realizados por difusão em discos previamente sensibilizados com extratos obtidos por maceração do caule e folhas nas concentrações de 50 e 100% (etanol 99,5ºGL como extrator). Realizaram-se testes para cepas Gram-positivas (Staphylococcus aureus e Streptococcus pyogenes) e Gram-negativas (Escherichia coli). Os discos sensibilizados foram dispostos nas placas de cultivo e essas incubadas a 37 ºC/24 horas. Os halos de inibição foram analisados por leitura visual. Os extratos concentrados (100%) da casca e folha apresentaram inibição contra Gram-positivas e Gram-negativas, sendo o obtido da folha mais eficaz. Na concentração de 50%, a inibição somente foi observada com o macerado das folhas. Os extratos da maceração das folhas apresentaram maior inibição contra Gram-negativos. A ação inibitória registrada para os extratos da Q. parviflora Mart. pode estar relacionada a sua composição fitoquímica, pois apresenta vários metabolitos secundários com atividade antimicrobiana. Porém, são necessários estudos complementares para comprovação da presença dos compostos secundários capazes de atuar na inibição de micro-organismos, além de testes como a microdiluição em caldo para auxiliar na confirmação da ação inibitória dos compostos presentes na Q. parviflora Mart.Palavras-chave: Antibiótico. Cerrado. Extratos Vegetais.AbstractAntimicrobial resistance to pathogens is mainly due to the irrational use of antibiotics and constitutes a threat to the control of infectious diseases. Studies of the antibacterial activities of plant extracts can provide alternatives for the antimicrobial treatment and, therefore, has aroused interest by the investigation for the potential of the Brazilian flora. It was aimed to  analyze the possible antibacterial activity of the species Qualea parviflora Mart. The tests were carried out by diffusion in disks previously sensitized with extracts obtained by stem maceration and leaves at concentrations of 50 and 100% (99.5 °GL ethanol as extractor). Tests were performed for Gram-positive strains (Staphylococcus aureus and Streptococcus pyogenes) and Gram-negative (Escherichia coli). The sensitized discs were placed in the culture plates and incubated at 37 °C / 24 hours. Inhibition halos were analyzed by visual reading. Concentrated (100%) extracts of bark and leaf showed inhibition against Gram-positive and Gram-negative, being the most effective leaf extract. At 50% concentration the inhibition was only observed with leaf maceration. Extracts from leaf maceration showed greater inhibition against Gram negative. The inhibitory action recorded for the extracts of Q. parviflora Mart. may be related to its phytochemical composition, since it presents several secondary metabolites with antimicrobial activity. However, further studies are necessary to prove the presence of secondary compounds capable to act in inhibition of microorganisms, as well as testing broth microdilution to assist in confirming the inhibitory action of the compounds present in Q. parviflora Mart. Keywords: Antibiotic. Cerrado. Plant Extracts.  AbstractAntimicrobial resistance to pathogens is mainly due to the irrational use of antibiotics and constitutes a threat to the control of infectious diseases. Studies of the antibacterial activities of plant extracts can provide alternatives for the antimicrobial treatment and, therefore, has aroused interest by the investigation for the potential of the Brazilian flora. It was aimed to  analyze the possible antibacterial activity of the species Qualea parviflora Mart. The tests were carried out by diffusion in disks previously sensitized with extracts obtained by stem maceration and leaves at concentrations of 50 and 100% (99.5 °GL ethanol as extractor). Tests were performed for Gram-positive strains (Staphylococcus aureus and Streptococcus pyogenes) and Gram-negative (Escherichia coli). The sensitized discs were placed in the culture plates and incubated at 37 °C / 24 hours. Inhibition halos were analyzed by visual reading. Concentrated (100%) extracts of bark and leaf showed inhibition against Gram-positive and Gram-negative, being the most effective leaf extract. At 50% concentration the inhibition was only observed with leaf maceration. Extracts from leaf maceration showed greater inhibition against Gram negative. The inhibitory action recorded for the extracts of Q. parviflora Mart. may be related to its phytochemical composition, since it presents several secondary metabolites with antimicrobial activity. However, further studies are necessary to prove the presence of secondary compounds capable to act in inhibition of microorganisms, as well as testing broth microdilution to assist in confirming the inhibitory action of the compounds present in Q. parviflora Mart. Keywords: Antibiotic. Cerrado. Plant Extracts.