The classification of traditional Minas cheese (TMC) from different regions is important to ensure authenticity. Different chemometric approaches were used to discriminate TMCs from three different regions (Serro, Canastra and Araxá) of Minas Gerais, Brazil. The data obtained from the literature were used to develop an artificial neural network and to obtain linear discriminant functions, which were able to classify 100% of cheeses from different regions as a function of physico‐chemical composition. Both chemometric methods can be very useful tools to discriminate TMC from different regions based on physico‐chemical data which are obtained in a very quick and simple way.