Objective: To describe the process of construction and validation of a manual of guidelines for cancer care to patients undergoing chemotherapy. Method: Descriptive research carried out from 2016 to 2017 from the stages: situational diagnosis; collection of information; summary and selection of content; text elaboration; creation of illustrations; consultation with specialists; public consultation with target group; adequacy of the manual; and evaluation of the Flesch Readability Index (FLI). The Delph Technique was used for the validation process, which was performed by 10 experts in the thematic area of the manual. The concordance index of at least 80% was considered to guarantee the validation of the material. Results: the items covered in the manual evaluation instrument were divided into three blocks: objectives, structure and presentation, and relevance that obtained the Concordance Index (CI) of 93.75%. Conclusion: the manual was considered valid for content and appearance. Patients undergoing chemotherapy and without professional follow-up and information can make them more sufferers, which contradicts the philosophy of palliative care to prevent human suffering in all dimensions of care, including spiritual, psychosocial.