The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.

tifactorial interference with donor T-cell maturation. Theoretically TCR GD rearrangement occurs earlier in T-cell maturation than that of TCR alpha-beta, making the GD population sensitive to early post-HSCT changes in immune homeostasis. Factors affecting the maturation and immunoregulatory properties of GD T-cells require further investigation, as does the prognostic role of TCR GD diversity in aGVHD.