Ozonation has been proven effective for the removal of endocrine disrupting chemicals (EDCs) in water. However, conventional ozonation processesare still limited by ozone low solubility and stability in water. These limitations may be overcome by mixing a prior ozoneloaded non-polar solvent with the aqueous solution. This two-phase ozonation process combines Liquid-liquid extraction and Ozonation (LLO). Decamethylcyclopentasiloxane (D5) was chosen as the solvent to be charged with ozone for its non-toxicity, reusability and high ozone solubility. A concurrent LLO column reactor was designed for the simultaneous degradation of three endocrine disrupting chemicals (EDCs) in water: Estrone (E1), 17βestradiol (E2) and 17α-estradiol (EE2). Results showed that 98% of EDCs were removed effectively from a solution initially concentrated at 1 mg L-1. The efficacy of the degradation depends essentially of the column feeding flow rate, the ozone dose and the operating pH. The generation of byproducts during EDCs degradation by LLO was also investigated in this study. For a complete removal of both EDCs and byproducts, the dose of ozone had to be doubled.